(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(pyridin-3-yl)acetamido)hexanoic acid | 1245942-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(pyridin-3-yl)acetamido)hexanoic acid
• CAS: 1245942-60-2
• 化学式: C₂₈H₂₉N₃O₅
• 分子量: 487.555
• InChiKey: WEBTWQLWAOTQRE-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  117.62
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  甲醇 、 、 (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(pyridin-3-yl)acetamido)hexanoic acid 、 Fmoc-L-丙氨酸 、 溶剂黄146 在 哌啶 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.25h， 以68%的产率得到(S)-methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-(2-(pyridin-3-yl)acetamido)hexanamido)propanoate
  参考文献：
  名称：

  Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2

  摘要：

  Sirtuins catalyze the NAD(+) dependent deacetylation of N-epsilon-acetyl lysine residues to nicotinamide, O '-acetyl- ADP-ribose (OAADPR) and N-epsilon-deacetylated lysine. Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the screening of novel N-epsilon-modified lysine containing inhibitors against SIRT1 and SIRT2. N-epsilon-Selenoacetyl and N-epsilon-isothiovaleryl were the most potent moieties found in this study, comparable to the widely studied N-epsilon-thioacetyl group. The N-epsilon-3,3-dimethylacryl and N-epsilon-isovaleryl moieties gave significant inhibition in comparison to the N-epsilon-acetyl group present in the substrates. In addition, the studied N-epsilon-alkanoyl, N-epsilon-alpha,beta-unsaturated carbonyl and N-epsilon-aroyl moieties showed that the acetyl binding pocket can accept rather large groups, but is sensitive to even small changes in electronic and steric properties of the N-epsilon-modification. These results are applicable for further screening of Ne-acetyl analogues. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.035
• 作为产物：
  描述：

  (S)-methyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(pyridin-3-yl)acetamido)hexanoate 在 水 、 calcium chloride 、 sodium hydroxide 、 溶剂黄146 作用下， 以 异丙醇 、 水 为溶剂， 反应 5.0h， 以73%的产率得到(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(pyridin-3-yl)acetamido)hexanoic acid
  参考文献：
  名称：

  Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2

  摘要：

  Sirtuins catalyze the NAD(+) dependent deacetylation of N-epsilon-acetyl lysine residues to nicotinamide, O '-acetyl- ADP-ribose (OAADPR) and N-epsilon-deacetylated lysine. Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the screening of novel N-epsilon-modified lysine containing inhibitors against SIRT1 and SIRT2. N-epsilon-Selenoacetyl and N-epsilon-isothiovaleryl were the most potent moieties found in this study, comparable to the widely studied N-epsilon-thioacetyl group. The N-epsilon-3,3-dimethylacryl and N-epsilon-isovaleryl moieties gave significant inhibition in comparison to the N-epsilon-acetyl group present in the substrates. In addition, the studied N-epsilon-alkanoyl, N-epsilon-alpha,beta-unsaturated carbonyl and N-epsilon-aroyl moieties showed that the acetyl binding pocket can accept rather large groups, but is sensitive to even small changes in electronic and steric properties of the N-epsilon-modification. These results are applicable for further screening of Ne-acetyl analogues. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.035