3-Isobutylpyrrolidine-2,5-dione | 164597-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-Isobutylpyrrolidine-2,5-dione
• 英文别名: 3-(2-methylpropyl)pyrrolidine-2,5-dione
• CAS: 164597-78-8
• 化学式: C₈H₁₃NO₂
• 分子量: 155.19
• InChiKey: VDLCHRONYAACTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] GREENER AND ECONOMIC PROCESS FOR PREPARATION OF PREGABALIN<br/>[FR] PROCÉDÉ ÉCOLOGIQUE ET ÉCONOMIQUE POUR LA PRÉPARATION DE PRÉGABALINE
  申请人：HIKAL LTD

  公开号：WO2020183376A1

  公开（公告）日：2020-09-17

  The present invention relates to an economical, enzyme catalyzed and commercially viable greener process for manufacturing Pregabalin of formula (I) in high yield with highchemical and chiral purity.

  本发明涉及一种经济、酶催化和商业可行的更环保的工艺，用于以高产率、高化学纯度和手性纯度制造化学式（I）的普拉巴林。
• PYRAZOLYL DERIVATIVES AS SYK INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150191461A1

  公开（公告）日：2015-07-09

  The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

  本发明提供了公式I的新型吡唑衍生物，它们是脾酪氨酸激酶的有效抑制剂，并可用于治疗和预防由该酶介导的疾病，如哮喘、慢性阻塞性肺疾病、类风湿性关节炎和癌症。
• Nitrilase from arabis alpina, its encoding gene, vector, recombinant bacterial strain and uses thereof
  申请人：Zhejiang University of Technology

  公开号：US10100297B2

  公开（公告）日：2018-10-16

  The disclosure provides a nitrilase from Arabis alpina, which belongs to genus Arabis, family brassicaceae. The disclosure further provides the encoding gene, vector, recombinant bacterial strain, and the application in the manufacturing of (S)-3-cyano-5-methylhexanoic acid. The wet resting cells containing nitrilase Aa-Nit can kinetically resolve racemic IBSN at 1.2 M with a 42% conversion rate in 15 hr and >99% ee value. The disclosure provides a regio- and stereoselective method for the preparation of (S)-3-cyano-5-methylhexanoic acid. This method provides an atom economical, mild, environmental friendly industrial method to manufacture (S)-3-cyano-5-methylhexanoic acid.

  该披露提供了一种来自高山岩芥（Arabis alpina）的腈水解酶，属于十字花科（Brassicaceae）属的岩芥属（Arabis）。该披露进一步提供了编码基因、载体、重组细菌菌株以及在制造（S）-3-氰基-5-甲基己酸中的应用。含有腈水解酶Aa-Nit的湿性静置细胞可以在15小时内以1.2 M的速率对混合物IBSN进行动力学分离，转化率为42％，ee值大于99％。该披露提供了一种区域和立体选择性的方法，用于制备（S）-3-氰基-5-甲基己酸。该方法提供了一种原子经济、温和、环保的工业制造（S）-3-氰基-5-甲基己酸的方法。
• Lubricating oil composition and additive concentrate for addition to lubricating oil
  申请人：EDWIN COOPER INC.

  公开号：EP0011497A1

  公开（公告）日：1980-05-28

  A lubricating oil composition formulated to exhibit improved rust and corrosion-inhibiting properties and comprising, in addition to lubricating oil, an oxyalkylated sorbitan triester of a fatty acid and an oxyethylated alkylphenol. The invention further includes an additive concentrate formulated for addition to lubricating oil and containing, for corrosion-inhibiting purposes, both an oxyethylated sorbitan triester of a fatty acid and an oxyethylated alkylphenol.

  一种润滑油组合物，经配制后具有更好的防锈和防腐蚀性能，除润滑油外，还包含一种脂肪酸的氧烷基化山梨糖醇三酯和一种氧乙基化烷基酚。 本发明还包括一种浓缩添加剂，经配制后可添加到润滑油中，为防腐蚀目的，还包含一种脂肪酸的氧乙基化山梨糖醇三酯和一种氧乙基化烷基酚。
• A lubricating oil composition, an additive concentrate for lubricating oil and a method for imparting anti-corrosion properties to lubricating oil
  申请人：EDWIN COOPER INC.

  公开号：EP0031990A1

  公开（公告）日：1981-07-15

  The invention is in the field of lubricating oils and the imparting of anti-corrosion properties thereto. Lubricating oil formulations, e.g. lubricating oil formulated for use in an engine crankcase, having improved anti-corrosion properties may be produced by the incorporation in the formulations of a minor amount of the combination of (a) a block-oxyalkylated trimethylol alkane containing an initial hydrophobic block of propyleneoxy and optionally random ethyleneoxy units and a terminal hydrophilic block of ethyleneoxy and optionally random propyleneoxy units and (b) an oxyethylated alkylphenol.

  本发明涉及润滑油及其防腐性能领域。润滑油配方，例如用于发动机曲轴箱的润滑油配方，可通过在配方中加入少量以下物质的组合来生产具有更好防腐蚀性能的润滑油配方：(a) 嵌段烷氧基化的三羟甲基烷，该烷烃含有由丙烯氧基单元和可选的无规乙烯氧基单元组成的初始疏水嵌段，以及由乙烯氧基单元和可选的无规丙烯氧基单元组成的末端亲水嵌段；(b) 氧乙基化的烷基酚。