5-[(6-chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylcarbamoyl]-4-[4-(2-hydroxyethoxy)phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester | 642487-75-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 5-[(6-chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylcarbamoyl]-4-[4-(2-hydroxyethoxy)phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 5-[(6-chloro-1,3-benzodioxol-5-yl)methyl-cyclopropylcarbamoyl]-4-[4-(2-hydroxyethoxy)phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate
• CAS: 642487-75-0
• 化学式: C₃₀H₃₅ClN₂O₇
• 分子量: 571.07
• InChiKey: NDMRSKIVJXDXSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  97.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS<br/>[FR] NOUVEAUX DERIVES DE TETRAHYDROPYRIDINE EN TANT QU'INHIBITEURS DE RENINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004002957A1

  公开（公告）日：2004-01-08

  The invention relates to novel tetrahydropyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  该发明涉及新型四氢吡啶衍生物及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有其中一个或多个这些化合物的药物组合物，特别是它们作为肾素抑制剂的用途。
• Novel tetrahydropyridine derivatives as renin inhibitors
  申请人：Bezencon Olivier

  公开号：US20060009497A1

  公开（公告）日：2006-01-12

  The invention relates to novel tetrahydropyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  本发明涉及新型四氢吡啶衍生物及相关化合物，以及它们作为药物组分在制备药物组合物中的应用。本发明还涉及相关方面，包括制备这些化合物的过程、含有其中一个或多个化合物的药物组合物，尤其是它们作为肾素抑制剂的应用。
• NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1519920A1

  公开（公告）日：2005-04-06