[1,1'-Biphenyl]-3-methanamine, 4'-methoxy-N-methyl- | 885950-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1,1'-Biphenyl]-3-methanamine, 4'-methoxy-N-methyl-
• 英文别名: 1-[3-(4-methoxyphenyl)phenyl]-N-methylmethanamine
• CAS: 885950-08-3
• 化学式: C₁₅H₁₇NO
• 分子量: 227.3
• InChiKey: XEWJTRJYNYFJBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PHOSPHOLINKED DYE ANALOGS WITH AN AMINO ACID LINKER
  申请人：Shen Gene

  公开号：US20120052507A1

  公开（公告）日：2012-03-01

  In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including muliple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

  在各种实施方式中，本发明提供了通过氨基酸或肽连接剂与另一物种相连的荧光染料。在一个示例实施方式中，染料通过氨基酸或肽连接剂与聚磷酸核酸相连。这些共轭物在单分子DNA测序和其他应用中有用。在各种实施方式中，染料部分是一种靛烷染料。高度带电的靛烷染料，例如包括多个磺酸盐，烷基磺酸盐，羧酸盐和/或烷基羧酸盐部分的靛烷染料，是本发明化合物中使用的靛烷染料的示例。
• Phospholinked Dye Analogs with an Amino Acid Linker
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150197794A1

  公开（公告）日：2015-07-16

  In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

  在各种实施方式中，本发明提供了通过氨基酸或肽连接剂与另一物种连接的荧光染料。在一个示例实施方式中，该染料通过氨基酸或肽连接剂与多聚磷酸核酸连接。这些结合物可用于单分子DNA测序和其他应用。在各种实施方式中，染料部分是一种靛蓝染料。高度带电的靛蓝染料，例如包括多个磺酸盐，烷基磺酸盐，羧酸盐和/或烷基羧酸盐基团的靛蓝染料，是本发明化合物中使用的靛蓝染料的例子。
• CINNAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1757591A1

  公开（公告）日：2007-02-28

  The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) -C≡C- or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.

  本发明涉及一种由式（I）表示的化合物： (其中Ar1代表可被1至3个取代基取代的咪唑基；Ar2代表可被1至3个取代基取代的吡啶基、嘧啶基或苯基；X1代表(1)-C≡C-或(2)可被取代的双键等；R1和R2代表例如可被取代的C1-6烷基或C3-8环烷基）或其药理学上可接受的盐，以及其作为药剂的用途。
• US8993737B2
  申请人：——

  公开号：US8993737B2

  公开（公告）日：2015-03-31
• US9499862B2
  申请人：——

  公开号：US9499862B2

  公开（公告）日：2016-11-22