4-[(3,4,5-Trimethoxyphenyl)methylamino]phenol | 150268-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(3,4,5-Trimethoxyphenyl)methylamino]phenol
• CAS: 150268-64-7
• 化学式: C₁₆H₁₉NO₄
• 分子量: 289.331
• InChiKey: IAOHQWRBQHIONA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[(3,4,5-Trimethoxyphenyl)methylamino]phenol 、 氯甲酰乙酸乙酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以77%的产率得到ethyl 3-((4-hydroxyphenyl)(3,4,5-trimethoxybenzyl)amino)-3-oxopropanoate
  参考文献：
  名称：

  Oxidative Carbon−Carbon Bond Formation in the Synthesis of Bioactive Spiro β-Lactams

  摘要：

  New oxidative dearomatization procedures leading to Spiro beta-lactams and oxindoles were developed. By a variation of the oxidative reaction conditions, the usefulness of phenolic amides, derived from 4-aminophenol, in the synthesis of structurally different types of molecules was demonstrated.

  DOI：

  10.1021/ol901005x

文献信息

• Oxidative Carbon−Carbon Bond Formation in the Synthesis of Bioactive Spiro β-Lactams
  作者：Jixuan Liang、Jingbo Chen、Fengxiang Du、Xianghui Zeng、Liang Li、Hongbin Zhang

  DOI：10.1021/ol901005x

  日期：2009.7.2

  New oxidative dearomatization procedures leading to Spiro beta-lactams and oxindoles were developed. By a variation of the oxidative reaction conditions, the usefulness of phenolic amides, derived from 4-aminophenol, in the synthesis of structurally different types of molecules was demonstrated.