(3,5-bis-trifluoromethyl-benzyl)-isopropyl-amine | 823188-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-bis-trifluoromethyl-benzyl)-isopropyl-amine
• 英文别名: N-[[3,5-bis(trifluoromethyl)phenyl]methyl]propan-2-amine
• CAS: 823188-89-2
• 化学式: C₁₂H₁₃F₆N
• 分子量: 285.232
• InChiKey: URJUCXUSCBMKSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PTEN binding compounds, formulations, and uses thereof
  申请人：University of South Florida

  公开号：US11078164B1

  公开（公告）日：2021-08-03

  Described herein are compounds and formulations thereof that can bind PTEN. Also described herein are methods of using the compounds and formulations thereof that can bind PTEN. In some embodiments, the method can include administering an amount of a compound or formulation described herein to a subject in need thereof.

  本文描述了可与 PTEN 结合的化合物及其制剂。本文还描述了使用可结合 PTEN 的化合物及其制剂的方法。在某些实施方案中，该方法可包括向有需要的受试者施用一定量的本文所述化合物或制剂。
• Methods of treating solid tumors with CCR2 antagonists
  申请人：CHEMOCENTRYX, INC.

  公开号：US11154556B2

  公开（公告）日：2021-10-26

  The present disclosure provides, inter alia, methods of treating a solid-tumor by administering an effective amount of a Chemokine Receptor 2 (CCR2) antagonist. Also provided herein are methods of reducing the number of macrophages in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In an additional aspect, the current disclosure further provides methods of increasing the number CD8+ T cells in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In some embodiments, the CCR2 antagonist has the formula I:

  本公开特别提供了通过施用有效量的趋化因子受体2（CCR2）拮抗剂来治疗实体瘤的方法。本文还提供了减少实体瘤微环境中巨噬细胞数量的方法，所述方法包括施用有效量的趋化因子受体2（CCR2）拮抗剂。在另一个方面，本公开进一步提供了增加实体瘤微环境中 CD8+ T 细胞数量的方法，所述方法包括施用有效量的趋化因子受体 2 (CCR2)拮抗剂。在某些实施方案中，CCR2拮抗剂具有式I：
• CCR2 MODULATORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20160340356A1

  公开（公告）日：2016-11-24

  Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.
• SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20180086756A1

  公开（公告）日：2018-03-29

  Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.
• PTEN BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF
  申请人：DAVÉ VRUSHANK G.

  公开号：US20190161450A1

  公开（公告）日：2019-05-30

  Described herein are compounds and formulations thereof that can bind PTEN. Also described herein are methods of using the compounds and formulations thereof that can bind PTEN. In some embodiments, the method can include administering an amount of a compound or formulation described herein to a subject in need thereof.