3-甲基水杨酸铜(I)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-甲基水杨酸铜(I)
• 中文别名: 2-羟基-3-甲基苯甲酸铜(I)
• 英文名称: Copper(1+);2-hydroxy-3-methylbenzoate
• 英文别名: copper(1+);2-hydroxy-3-methylbenzoate
• 化学式: C8H7CuO3
• 分子量: 214.68
• InChiKey: CPPQOSMKJDPRID-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE<br/>[FR] INHIBITEURS À PETITE MOLÉCULE DE KINASE INDUISANT NF-KB
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2020239999A1

  公开（公告）日：2020-12-03

  The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

  本发明涉及抑制NIK的化合物，以及包含这些化合物的药物组合物和使用方法。这些化合物和药物组合物预期能用于预防或治疗癌症（如包括白血病、淋巴瘤和多发性骨髓瘤的B细胞恶性肿瘤）、炎症性疾病、自身免疫疾病、免疫皮肤病学疾病（如掌跖脓疱病和化脓性汗腺炎）以及代谢紊乱疾病（如肥胖和糖尿病）。
• [EN] BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS<br/>[FR] INHIBITEURS DE LA DIHYDROOROTATE DÉSHYDROGÉNASE BI-ARYLE
  申请人：JANSSEN BIOTECH INC

  公开号：WO2021070132A1

  公开（公告）日：2021-04-15

  Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, and Q are defined herein.

  披露了用于治疗受DHODH调制影响的疾病、失调或医疗条件的化合物、组合物和方法。这些化合物由以下式I表示：式I其中R1、R2、R3和Q在此定义。
• [EN] PROCESS FOR PREPARING A COT INHIBITOR COMPOUND<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ INHIBITEUR DE COT
  申请人：GILEAD SCIENCES INC

  公开号：WO2021202688A1

  公开（公告）日：2021-10-07

  Disclosed are syntheses of a Cot (cancer Osaka thyroid) inhibitor, which has the formula (I).

  公开了一种Cot（大阪甲状腺癌）抑制剂的合成方法，其化学公式为（I）。
• Process for the preparation of azidoperfluoroalkanes and N-polyfluoroalkyl azides
  申请人：Ustav organicke chemie a biochemie AV CR, v.v.i.

  公开号：US20190161452A1

  公开（公告）日：2019-05-30

  Process for the preparation of azidoperfluoroalkanes and azidopolyfluoroalkanes of general formula R F —N 3 , where R F is chosen from a group containing C n F 2n+1 , C n F x H 2n+1−x , C n F x X 2n+1−x or R 1 CF 2 CF 2 , where n is an integer in the range of 1 to 10, x is an integer in the range of 2 to 20, X is Cl, Br, or I, R 1 is C 1-10 alkyl, ArO, ArS, imidazolyl, benzimidazolyl, or pyrazolyl and Ar is phenyl or substituted phenyl, by the reaction of electrophilic azidation reagent of general formula R 2 —N 3 , where R 2 is n-C 4 F 9 SO 2 , ArSO 2 , Br, I, with synthetic equivalent of polyfluoroalkylated carbanion of general formula [R F ] − .

  通用公式RF—N3的叠氮全氟烷和叠氮多氟烷的制备过程，其中RF选择自包含CnF2n+1、CnFxH2n+1−x、CnFxX2n+1−x或R1CF2CF2的一组化合物，其中n为1至10范围内的整数，x为2至20范围内的整数，X为Cl、Br或I，R1为C1-10烷基、ArO、ArS、咪唑基、苯并咪唑基或吡唑基，Ar为苯基或取代苯基，通过亲电性叠氮试剂R2—N3的反应，其中R2为n-C4F9SO2、ArSO2、Br、I的通用公式，与通用公式[RF]−的多氟烷基化碳负离子的合成等效物的反应。
• 5-Phenyl[1,2,4]triazines as ligands for GABA-A alpha2/alpha3 receptors for treating anxiety or depression
  申请人：——

  公开号：US20040192692A1

  公开（公告）日：2004-09-30

  The present invention provides a compound of formula I, or an N-oxide thereof or a pharmaceutically acceptable salt thereof: 1 wherein X 1 represents hydrogen, halogen, C 1-6 alkyl, trifluoromethyl or C 1-6 alkoxy; X 2 represents hydrogen or halogen; Z represents hydrogen, halogen, cyano, cyanomethyl, trifluoromethyl, nitro, hydroxy, hydroxy(C 1-6 )alkyl, C 1-6 alkoxy, C 1-6 alkoxy(C 1-6 )alkyl, trifluoromethoxy, trifluoromethylthio, trifluoromethanesulfinyl, formyl, C 2 - 6 alkoxycarbonyl, oxopyrrolidinyl, or an optionally substituted aryl, heteroaryl or heteroaryl(C 1-6 )alkoxy group; and R 1 represents aryl or heteroaryl, either of which groups may be optionally substituted; pharmaceutical compositions comprising it, its use in therapy and methods of treatment of anxiety and/or depression using it.

  本发明提供了一种具有以下式I的化合物，或其N-氧化物或药用可接受的盐：其中X1代表氢、卤素、C1-6烷基、三氟甲基或C1-6烷氧基；X2代表氢或卤素；Z代表氢、卤素、氰基、氰甲基、三氟甲基、硝基、羟基、羟基(C1-6)烷基、C1-6烷氧基、C1-6烷氧基(C1-6)烷基、三氟甲氧基、三氟甲基硫基、三氟甲磺基、甲酰基、C2-6烷氧羰基、氧代吡咯烷基，或者是一种可选择取代的芳基、杂环芳基或杂环芳基(C1-6)烷氧基团；R1代表芳基或杂环芳基，其中这些基可能是可选择取代的；包括它的药物组合物、其在治疗中的用途以及使用它进行焦虑和/或抑郁治疗的方法。