3-Dibromomethyl-phenol | 70970-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-Dibromomethyl-phenol
• 英文别名: 3-(Dibromomethyl)phenol
• CAS: 70970-05-7
• 化学式: C₇H₆Br₂O
• 分子量: 265.932
• InChiKey: OKDYXZXARZZDPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-Dibromomethyl-phenol 、 potassium thioacetate 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Thiol-Activatedgem-Dithiols: A New Class of Controllable Hydrogen Sulfide Donors

  摘要：

  A class of novel thiol-activated H2S donors has been developed on the basis of the gem-dithiol template. These donors release H2S in the presence of cysteine or GSH in aqueous solutions as well as in cellular environments.

  DOI：

  10.1021/ol502088m
• 作为产物：
  描述：

  间羟基苯甲醛 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 3-Dibromomethyl-phenol
  参考文献：
  名称：

  Thiol-Activatedgem-Dithiols: A New Class of Controllable Hydrogen Sulfide Donors

  摘要：

  A class of novel thiol-activated H2S donors has been developed on the basis of the gem-dithiol template. These donors release H2S in the presence of cysteine or GSH in aqueous solutions as well as in cellular environments.

  DOI：

  10.1021/ol502088m

文献信息

• Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0587311A1

  公开（公告）日：1994-03-16

  Compounds of formula (I) : [wherein: R¹ is hydrogen, alkyl, aralkyl, -CORa, -CORb, -CSRa, -CSRb, -SO₂Rb, -CONHRb, -CSNHRb, -CONRbRb or -CSNRbRb; R² is hydrogen or alkyl; R³ is hydrogen, alkylidene, substituted alkyl, or Rb; R⁴ is optionally substituted alkyl, cycloalkyl, or aryl; R⁵ is RbO-, RbRbN-, RbHN-, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R⁵ is -(CH₂)p-D-(CH₂)r- [where D is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and p and r are each 0 or an integer from 1 to 5]; A is -(CH₂)m-B-(CH₂)n- [where B is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and m and n are each 0 or an integer from 1 to 5]; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl]; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.

  化合物的化学式为(I)：[其中：R¹为氢，烷基，芳基烷基，-CORa，-CORb，-CSRa，-CSRb，-SO₂Rb，-CONHRb，-CSNHRb，-CONRbRb或-CSNRbRb；R²为氢或烷基；R³为氢，烷基亚甲基，取代烷基或Rb；R⁴为可选取代的烷基，环烷基或芳基；R⁵为RbO-，RbRbN-，RbHN-，芳基烷氧羰氧基氧或芳基烷氧羰氨基，或R⁵为-(CH₂)p-D-(CH₂)r- [其中D为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；p和r分别为0或1到5的整数]；A为-(CH₂)m-B-(CH₂)n- [其中B为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；m和n分别为0或1到5的整数]；Ra为烷氧基，芳基烷氧基，芳氧基或烷氧羰基；Rb为可选取代的烷基，环烷基，杂环，芳基或芳基烷烯基]；以及其药学上可接受的盐和酯以及其前药，具有抑制HIV蛋白酶活性的能力，因此可用于治疗和预防艾滋病。
• Lansinger,J.M.; Ronald,R.C., Synthetic Communications, 1979, vol. 9, p. 341 - 349
  作者：Lansinger,J.M.、Ronald,R.C.

  DOI：——

  日期：——
• LANSINGER J. M.; ROLAND R. C., SYNTH. COMMUN., 1979, 9, NO 4, 341-349
  作者：LANSINGER J. M.、 ROLAND R. C.

  DOI：——

  日期：——
• PHOSPHONATE-SUBSTITUTED LIGNIN AS A FLAME RETARDANT
  申请人：Brizius Glen Leon

  公开号：US20130292615A1

  公开（公告）日：2013-11-07

  Modified lignin having covalently attached phosphorous containing groups and methods for preparing such compounds are described herein. The modified lignin described herein provides a renewable source of flame retardant material.
• US5629406A
  申请人：——

  公开号：US5629406A

  公开（公告）日：1997-05-13