4-(3-(3-((1,1-dioxidothiomorpholino)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide | 1237645-11-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-(3-((1,1-dioxidothiomorpholino)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide
• 英文别名: 4-(3-(3-(imino(1,1-dioxidothiomorpholine)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide；1-[3-(1,1-Dioxo-1,4-thiazinane-4-carboximidoyl)phenyl]-3-[4-[(4-sulfamoylphenyl)methylsulfamoyl]phenyl]urea
• CAS: 1237645-11-2
• 化学式: C₂₅H₂₈N₆O₇S₃
• 分子量: 620.731
• InChiKey: FYJICTRYSLCKEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  234
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• NOVEL SULFAMOYL-PHENYL-UREIDO COMPOUNDS AND THEIR USE AS MEDICAMENT
  申请人：PEGORARO Stefano

  公开号：US20100197640A1

  公开（公告）日：2010-08-05

  The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated or severe malaria caused by plasmodia.

  本发明涉及具有化学式（I）的新型磺胺酰基苯基脲类化合物或其生理上可接受的盐或衍生物，适用于治疗由原虫引起的感染，特别是由疟原虫引起的非并发或严重疟疾。
• SULFAMOYL- PHENYL-UREIDO BENZAMIDINE-DERIVATIVES AS ANTIMALARIAL AGENTS
  申请人：4SC AG

  公开号：EP2391601A1

  公开（公告）日：2011-12-07
• US8343963B2
  申请人：——

  公开号：US8343963B2

  公开（公告）日：2013-01-01
• [EN] SULFAMOYL- PHENYL-UREIDO BENZAMIDINE-DERIVATIVES AS ANTIMALARIAL AGENTS<br/>[FR] DÉRIVÉS DE SULFAMOYL-PHÉNYL-URÉIDO-BENZAMIDINE EN TANT QU'AGENTS ANTIPALUDÉENS
  申请人：4SC AG

  公开号：WO2010086177A1

  公开（公告）日：2010-08-05

  The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated or severe malaria caused by plasmodia.