(2R,3S)-4-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-4-phenyl-3-(4-pyridinylamino)-2-butanol | 1154096-69-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3S)-4-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-4-phenyl-3-(4-pyridinylamino)-2-butanol
• 英文别名: (2R,3S)-1-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-4-phenyl-3-(pyridin-4-ylamino)butan-2-ol
• CAS: 1154096-69-1
• 化学式: C₂₉H₃₅N₃O₂
• 分子量: 457.616
• InChiKey: JOVIUSQKJDBBGD-GMQQYTKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  66.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SUBSTITUTED PYRANO [2,3-B] PYRIDINAMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE
  申请人：GRACEFFA Russell

  公开号：US20100317668A1

  公开（公告）日：2010-12-16

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , X and Z are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions. The invention also comprises further embodiments of Formula II, intermediates and processes useful for the preparation of compounds of Formulas I and II.

  本发明涉及一类新的化合物，可用于调节Beta-秘酶酶活性，并用于治疗Beta-秘酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一种实施例中，该化合物具有一般的I式，其中R1、R2、R3、R4、R5、A1、A2、A3、A4、X和Z在此定义。本发明还包括将这些化合物用于制备药物组合物，以治疗与beta-秘酶蛋白活性相关的疾病和症状，例如阿尔茨海默病（AD）、认知缺陷和损伤、精神分裂症和其他类似的中枢神经系统疾病。本发明还包括II式的进一步实施例、中间体和制备I式和II式化合物的有用过程。
• US7951838B2
  申请人：——

  公开号：US7951838B2

  公开（公告）日：2011-05-31