N-(2-Hydroxybenzyl)-salicylsaeureamid | 28023-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-Hydroxybenzyl)-salicylsaeureamid
• 英文别名: 2-hydroxy-N-[(2-hydroxyphenyl)methyl]benzamide
• CAS: 28023-83-8
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: XQVUBJROCNXHGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] CRYSTALLINE FORM OF 2-(2-HYDROXY PHENYL)BENZ[E][1,3]OXAZIN-4-ONE, PROCESS FOR THE SAME AND USE FOR PRODUCING 4-(3,5-BIS(2-HYDROXYPHENYL)-1H-1,2,4-TRIAZOL-1-YL)BENZOIC ACID<br/>[FR] FORME CRISTALLINE DE LA 2-(2-HYDROXYPHÉNYL)BENZ[E][1,3]OXAZIN-4-ONE, SON PROCÉDÉ DE PRODUCTION ET SON UTILISATION POUR PRODUIRE L'ACIDE 4-(3,5-BIS(2-HYDROXYPHÉNYL)-1H-1,2,4-TRIAZOL-1-YL)BENZOÏQUE
  申请人：MATRIX LAB LTD

  公开号：WO2010023685A2

  公开（公告）日：2010-03-04

  The present invention relates to a crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-one, a process for production thereof and its use in the preparation of 4- (3, 5-bis (2-hydroxyphenyl)-1H-1, 2, 4-triazol-1-yl) benzoic acid. The improved process for the preparation 4-(3,5-bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl) benzoic acid (Deferasirox), wherein salicylic chloride is reacted with salicylamide in presence of a solvent to give acyl compound, which is heated to higher temperature in-situ to undergo cyclization to obtain crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-on and further reaction with hydrazino benzoic acid to give 4-(3,5- bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid.