9-(but-3-en-1-yl)-6-(piperidin-1-yl)-9H-purine | 1447825-15-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(but-3-en-1-yl)-6-(piperidin-1-yl)-9H-purine
• CAS: 1447825-15-1
• 化学式: C₁₄H₁₉N₅
• 分子量: 257.338
• InChiKey: BXMRFCUWRPJGIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.39
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.84
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  6-烯丙氧基-4-甲基-色烯-2-酮 、 9-(but-3-en-1-yl)-6-(piperidin-1-yl)-9H-purine 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以58%的产率得到4-methyl-6-{[(2E)-6-(6-piperidin-1-yl-9H-purin-9-yl)-pent-2-en-1-yl]oxy}-2H-chromen-2-one
  参考文献：
  名称：

  Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers^*

  摘要：

  Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6-or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their antioxidant activity and they present significant scavenging activity. The presence of a pentenyloxy moiety, the attachment position on coumarin ring as well as a purine homo-N-nucleoside group are considered as important structural features.

  DOI：

  10.3109/14756366.2012.684050
• 作为产物：
  描述：

  4-溴-1-丁烯 、 6-哌啶嘌呤 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以70%的产率得到9-(but-3-en-1-yl)-6-(piperidin-1-yl)-9H-purine
  参考文献：
  名称：

  Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers^*

  摘要：

  Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6-or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their antioxidant activity and they present significant scavenging activity. The presence of a pentenyloxy moiety, the attachment position on coumarin ring as well as a purine homo-N-nucleoside group are considered as important structural features.

  DOI：

  10.3109/14756366.2012.684050