Bms-347070 | 197438-73-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bms-347070
• 英文别名: (3Z)-3-[(4-bromophenyl)-(4-methylsulfonylphenyl)methylidene]oxolan-2-one
• CAS: 197438-73-6
• 化学式: C₁₈H₁₅BrO₄S
• 分子量: 407.3
• InChiKey: KOWIZHDULJSRPT-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  生成 Bms-347070
  参考文献：
  名称：

  US6180651B1

  摘要：

  公开号：

文献信息

• NOUVEAUX DERIVES DIARYLMETHYLIDENE FURANIQUES, LEURS PROCEDES DE PREPARATION ET LEURS UTILISATIONS EN THERAPEUTIQUE
  申请人：LABORATOIRES UPSA

  公开号：EP0891345B1

  公开（公告）日：2001-08-16
• COFORMULATION METHODS AND THEIR PRODUCTS
  申请人：Bradford Particle Design Limited

  公开号：EP1207856A2

  公开（公告）日：2002-05-29
• Formulations of low solubility bioactive agents and processes for making the same
  申请人：——

  公开号：US20040185110A1

  公开（公告）日：2004-09-23

  A method of coprocessing a limited solubility bioactive agent with a compatible aid comprising: (a) identifying a compatible aid for the bioactive agent; (b) either (i) forming a co-dissolved solution of the compatible aid and bioactive agent in a common solvent or (ii) forming a solution of the compatible aid in an anti-solvent and forming solution of the bioactive agent in a solvent; and (c) forming a film or primary particles from the co-dissolved solution or solutions of step (b), which film or primary particles comprise bioactive agent in crystalline form, with the crystals having average diameter of 1 micron or less.
• [EN] COFORMULATION METHODS AND THEIR PRODUCTS<br/>[FR] PROCEDES DE COFORMULATION ET LEURS PRODUITS
  申请人：BRADFORD PARTICLE DESIGN PLC

  公开号：WO2001015664A2

  公开（公告）日：2001-03-08

  A coformulation of an active (preferably pharmaceutically active, for instance a COX-2 enzyme inhibitor) substance and an oligomeric or polymeric excipient, containing at least 10 % of the active, between 80 and 100 % of which is amorphous. The amorphous phase is stable, with respect to the crystalline phase(s), for at least theree months after its preparation when stored at between O and 10 °C. The invention also provides processes, preferably involving SEDSTM particle formation, for preparing such a coformulation.
• [EN] FORMULATIONS OF LOW SOLUBILITY BIOACTIVE AGENTS AND PROCESSES FOR MAKING THE SAME<br/>[FR] PREPARATIONS D'AGENTS BIOACTIFS PEU SOLUBLES ET PROCEDES POUR LES PRODUIRE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004043358A2

  公开（公告）日：2004-05-27

  A method of coprocessing a limited solubility bioactive agent with a compatible aid comprising: (a) identifying a compatible aid for the bioactive agent; (b) either (i) forming a co-dissolved solution of the compatible aid and bioactive agent in a common solvent or (ii) forming a solution of the compatible aid in an anti-solvent and forming solution of the bioactive agent in a solvent; and (c) forming a film or primary particles from the co-dissolved solution or solutions of step (b), which film or primary particles comprise bioactive agent in crystalline form, with the crystals having average diameter of 1 micron or less.