N,N'-Thiodimaleimid | 15395-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N,N'-Thiodimaleimid
• 英文别名: Maleimido-thioether；1-(2,5-dioxopyrrol-1-yl)sulfanylpyrrole-2,5-dione
• CAS: 15395-93-4
• 化学式: C₈H₄N₂O₄S
• 分子量: 224.197
• InChiKey: OJCNHTCSMRAQJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• [EN] STABILE CONJUGATE<br/>[FR] CONJUGUÉ STABLE
  申请人：GLYKOS BIOMEDICAL OY

  公开号：WO2021123506A1

  公开（公告）日：2021-06-24

  A conjugate is disclosed. The conjugate may be represented by Formula I: [D-O-L]n-T Formula I wherein D is a payload molecule; O is an oxygen atom of said payload molecule; T is a targeting unit capable of binding a target molecule, cell and/or tissue; and n is at least 1.

  本发明揭示了一种共轭物。该共轭物可以用公式I表示：[D-O-L]n-T 公式I，其中D是荷载分子；O是所述荷载分子的氧原子；T是能够结合目标分子、细胞和/或组织的靶向单元；n至少为1。
• Derivatives of amphetamine, antibodies against said derivatives, reagent kits, methods of producing said antibodies, and methods of detecting said derivatives
  申请人：Roche Diagnostics GmbH

  公开号：EP1340980A1

  公开（公告）日：2003-09-03

  Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, reagent kits containing antibodies specific for the methylenedioxy class of amphetamine derivatives, methods of producing antibodies specific for the methylenedioxy class of amphetamine derivatives, and methods of detecting analytes including members of the methylenedioxy class of amphetamine derivatives are also described.

  本文描述了在生产特异性针对亚甲二氧基类安非他命衍生物的抗体中有用的包括半抗原、中间体和免疫原的化合物。还描述了特异性针对亚甲二氧基类安非他命衍生物的抗体、含有特异性针对亚甲二氧基类安非他命衍生物的抗体的试剂盒、制备特异性针对亚甲二氧基类安非他命衍生物的抗体的方法以及检测包括亚甲二氧基类安非他命衍生物成员的分析物的方法。
• Antibodies for detecting ecstasy-class analytes
  申请人：Roche Diagnostics GmbH

  公开号：EP1498428A1

  公开（公告）日：2005-01-19

  Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, reagent kits containing antibodies specific for the methylenedioxy class of amphetamine derivatives, methods of producing antibodies specific for the methylenedioxy class of amphetamine derivatives, and methods of detecting analytes including members of the methylenedioxy class of amphetamine derivatives are also described.

  本文描述了包括半抗原、中间体和免疫原在内的化合物，这些化合物对于生产特异性针对亚甲二氧基类安非他命衍生物的抗体是有用的。本文还描述了特异性针对亚甲二氧基类安非他命衍生物的抗体、包含特异性针对亚甲二氧基类安非他命衍生物的抗体的试剂盒、生产特异性针对亚甲二氧基类安非他命衍生物的抗体的方法以及检测分析物，包括亚甲二氧基类安非他命衍生物成员的方法。
• Compounds, antibodies, reagent kits, methods of producing antibodies, and methods of detecting analytes
  申请人：Roche Diagnostics Corporation

  公开号：US20030170917A1

  公开（公告）日：2003-09-11

  Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, reagent kits containing antibodies specific for the methylenedioxy class of amphetamine derivatives, methods of producing antibodies specific for the methylenedioxy class of amphetamine derivatives, and methods of detecting analytes including members of the methylenedioxy class of amphetamine derivatives are also described.

  本文介绍了一些有用的化合物，包括半抗原、中间体和免疫原，这些化合物可用于生产特异性针对甲基二氧苯丙胺衍生物的抗体。本文还介绍了特异性针对甲基二氧苯丙胺衍生物的抗体、含有特异性针对甲基二氧苯丙胺衍生物的抗体的试剂盒、制备特异性针对甲基二氧苯丙胺衍生物的抗体的方法以及检测包括甲基二氧苯丙胺衍生物成员的分析物的方法。