trans-3'-Hydroxymethylnicotin | 33224-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: trans-3'-Hydroxymethylnicotin
• 英文别名: (1-methyl-2-pyridin-3-yl-pyrrolidin-3-yl)-methanol；3'-hydroxymethyl-nicotine；trans-3'-hydroxymethylnicotine；[(2S,3S)-1-methyl-2-pyridin-3-ylpyrrolidin-3-yl]methanol
• CAS: 33224-02-1
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: JJGXQIZRJPRSOS-GHMZBOCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Hapten-carrier conjugates and uses thereof
  申请人：Bachmann F. Martin

  公开号：US20050281845A1

  公开（公告）日：2005-12-22

  The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

  本发明提供了一种包含半抗原与载体的共轭物的组合物，其具有有序和重复的排列方式，并提供了制备这种组合物的方法。本发明的共轭物和组合物可以包含各种半抗原，包括激素、毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和共轭物可用于诱导免疫反应，用于各种治疗、预防和诊断方案。在某些实施例中，使用本发明的共轭物、组合物和方法产生的免疫反应可用于预防或治疗药物成瘾及与药物成瘾相关的疾病。
• MULTIVALENT SYNTHETIC NANOCARRIER VACCINES
  申请人：Bratzler Robert L.

  公开号：US20110293701A1

  公开（公告）日：2011-12-01

  The invention relates, at least in part, to compositions comprising populations of synthetic nanocarriers that comprise different sets of antigens as well as related methods.

  该发明涉及至少部分包含不同抗原集合的合成纳米载体群体的组成物，以及相关方法。
• Hapten-Carrier Conjugates and Uses Thereof
  申请人：BACHMANN Martin F.

  公开号：US20130142821A1

  公开（公告）日：2013-06-06

  The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

  本发明提供了一种由载体和半抗原共价结合的有序和重复阵列的组合物及其制备方法。该发明的共价结合物和组合物可以包含多种半抗原，包括激素、毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和共价结合物可用于诱导对半抗原的免疫反应，这对于各种治疗、预防和诊断方案都有用。在某些实施例中，使用本发明的共价结合物、组合物和方法产生的免疫反应可用于预防或治疗药物成瘾及与药物成瘾相关的疾病。
• NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE
  申请人：Kem William Reade

  公开号：US20130157995A1

  公开（公告）日：2013-06-20

  Embodiments of the present disclosure provide for compounds such as those shown in FIG. 1.1 (compounds A, B, C, and D), 2′substituted nicotine compounds, azetidine compounds, ether linked nicotine compounds (FIG. 1.2 , compounds E, F, G, and H), methods of synthesis of the compounds, methods of treatment of a condition using compounds A, B, C, D, 2′substituted nicotine compounds, azetidine compounds, or ether linked nicotine compounds, methods of selectively stimulating alpha7 nAChR and/or alpha4beta2 receptors, and the like.

  本公开的实施例提供了化合物，例如图1.1所示的化合物A、B、C和D，2'取代尼古丁化合物，氮杂环化合物，以太键结合的尼古丁化合物（图1.2，化合物E、F、G和H），化合物的合成方法，使用化合物A、B、C、D、2'取代尼古丁化合物、氮杂环化合物或以太键结合的尼古丁化合物治疗疾病的方法，选择性刺激α7 nAChR和/或α4beta2受体的方法等。
• Hapten-carrier conjugates for treating and preventing nicotine addiction
  申请人：Nabi Biopharmaceuticals

  公开号：EP1512414A1

  公开（公告）日：2005-03-09

  Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(-) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.

  新型合物-载体共轭物能够在体内诱导产生与尼古丁特异性结合的抗体。这些共轭物由与免疫原性载体蛋白共轭的尼古丁合剂组成。这些新型共轭物保留了尼古丁原生 (S)-(-) 态的手性，并具有良好的稳定性。这种共轭物可用于配制主动免疫疫苗，用于预防和治疗尼古丁成瘾。针对尼古丁合剂-载体共轭物产生的抗体可用于被动免疫。这些抗体可用于预防和治疗尼古丁成瘾。