4a(2)-Bromo-N-methyl[1,1a(2)-biphenyl]-4-sulfonamide | 501944-44-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4a(2)-Bromo-N-methyl[1,1a(2)-biphenyl]-4-sulfonamide
• 英文别名: 4-(4-bromophenyl)-N-methylbenzenesulfonamide
• CAS: 501944-44-1
• 化学式: C₁₃H₁₂BrNO₂S
• 分子量: 326.21
• InChiKey: HEHYLBSBSGYHFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Thiophenylthiopyrane dioxides as mmp or tnf-alpha inhibitors
  申请人：——

  公开号：US20040266826A1

  公开（公告）日：2004-12-30

  A compound of the formula: in which R 1 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted bicyclic heterocyclic group, optionally substituted lower alkenyl or optionally substituted lower alkynyl, and R 2 is carboxy or protected carboxy, or a salt thereof, useful for treating and/or preventing MMP- or TNF-&agr; mediated diseases. 1

  一种化合物的公式：其中R1为可选取的取代苯基、可选取的取代萘基、可选取的取代双环杂环基、可选取的取代较低烯基或可选取的取代较低炔基，R2为羧基或保护羧基，或其盐，用于治疗和/或预防MMP或TNF-α介导的疾病。
• THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1423386A1

  公开（公告）日：2004-06-02
• [EN] THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS<br/>[FR] BIOXYDES DE THIOPHENYLTHIOPYRANE INHIBITEURS DU MMP- OU DU TNF-ALPHA
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003022842A1

  公开（公告）日：2003-03-20

  A compound of the formula : in which R1 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted bicyclic heterocyclic group, optionally substituted lower alkenyl or optionally substituted lower alkynyl, and R2 is carboxy or protected carboxy, or a salt thereof, useful for treating and/or preventing MMP- or TNF-α mediated diseases.