2-((2R,3R)-1-((S)-2-benzyl-5,5-dimethyl-3-oxoisothiazolidin-4-yl)-2-chloro-4-oxoazetidin-3-yl)isoindoline-1,3-dione | 232925-05-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 2-((2R,3R)-1-((S)-2-benzyl-5,5-dimethyl-3-oxoisothiazolidin-4-yl)-2-chloro-4-oxoazetidin-3-yl)isoindoline-1,3-dione
• 英文别名: 2-[(2R,3R)-2-chloro-1-[(4S)-5,5-dimethyl-3-oxo-2-(phenylmethyl)-4-isothiazolidinyl]-4-oxo-3-azetidinyl]-1H-isoindole-1,3(2H)-dione；2-[(2R,3R)-1-[(4S)-2-benzyl-5,5-dimethyl-3-oxo-1,2-thiazolidin-4-yl]-2-chloro-4-oxoazetidin-3-yl]isoindole-1,3-dione
• CAS: 232925-05-2
• 化学式: C₂₃H₂₀ClN₃O₄S
• 分子量: 469.948
• InChiKey: QOGFTUVAMGIIMG-BZSNNMDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S,5R,6R)-N-benzyl-6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxamide 在 磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以1%的产率得到2-((2R,3R)-1-((S)-2-benzyl-5,5-dimethyl-3-oxoisothiazolidin-4-yl)-2-chloro-4-oxoazetidin-3-yl)isoindoline-1,3-dione
  参考文献：
  名称：

  Azetidinone-isothiazolidinones: Stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams

  摘要：

  A simple and efficient procedure for the stereoselective synthesis of new azetidinone-isothiazolidinones has been developed. New compounds were tested in vitro on a panel of Gram-positive and Gram-negative bacterial pathogens, some of them showing weak antibacterial activity. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.03.045

文献信息

• Silver halide photosensitive material and isothiazolidine-3-one derivative
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20030190566A1

  公开（公告）日：2003-10-09

  A silver halide photosensitive material contains a compound of the following general formula (I): 1 wherein A 1a represents a group selected from among CR 1a R 2a , NR 1a , an oxygen atom and sulfur atom, A 1b represents a group selected from among CR 1b R 2b , NR 1b , an oxygen atom and sulfur atom, and each of R 1a , R 2a , R 1b , R 2b and R 3 represents a hydrogen atom or a substituent, provided that, in the groups of CR 1a R 2a and CR 1b R 2b , R 1a R 2a and R 1b R 2b may represent a single divalent substituent, n represents an integer of 1 to 4, provided that, when n is 2 or more, a plurality of A 1b s may be the same or different.

  一种银卤片光敏材料包含下列通式（I）的化合物：1其中A1a代表从CR1aR2a，NR1a，氧原子和硫原子中选择的基团，A1b代表从CR1bR2b，NR1b，氧原子和硫原子中选择的基团，R1a，R2a，R1b，R2b和R3中的每一个代表氢原子或取代基，但在CR1aR2a和CR1bR2b的基团中，R1aR2a和R1bR2b可以表示为单个的二价取代基，n表示1至4的整数，但当n为2或更多时，多个A1b可以相同或不同。
• Azetidinone-isothiazolidinones: Stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams
  作者：Helena Cerić、Marija Šindler-Kulyk、Miće Kovačević、Mihaela Perić、Andreja Živković

  DOI：10.1016/j.bmc.2010.03.045

  日期：2010.5

  A simple and efficient procedure for the stereoselective synthesis of new azetidinone-isothiazolidinones has been developed. New compounds were tested in vitro on a panel of Gram-positive and Gram-negative bacterial pathogens, some of them showing weak antibacterial activity. (c) 2010 Elsevier Ltd. All rights reserved.