1,1'-Methylenebis(4-((hydroxyimino)methyl)-pyridinium) dimethanesulfonate | 1187073-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,1'-Methylenebis(4-((hydroxyimino)methyl)-pyridinium) dimethanesulfonate
• 英文别名: N-[[1-[[4-(hydroxyiminomethyl)pyridin-1-ium-1-yl]methyl]pyridin-1-ium-4-yl]methylidene]hydroxylamine;methanesulfonate
• CAS: 1187073-73-9
• 化学式: C15H20N4O8S2
• 分子量: 448.5
• InChiKey: LIBNJJLUCYWGII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.59
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  200
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Dosage suspensions of active pharmaceutical ingredients
  申请人：Southwest Research Institute

  公开号：US10117859B2

  公开（公告）日：2018-11-06

  Methods for preparing suspensions of active pharmaceutical ingredients for ensuing drug delivery. The suspension may include a mixture of a relatively low dosage API and a relatively high dosage API or a mixture of an API with a suitable excipient.

  制备用于随后给药的活性药物成分悬浮液的方法。悬浮液可包括剂量相对较低的原料药和剂量相对较高的原料药的混合物，或原料药与适当赋形剂的混合物。
• Polymer engineered regenerating bioscavengers
  申请人：Carnegie Mellon University

  公开号：US10400232B2

  公开（公告）日：2019-09-03

  Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

  本发明的实施例提供了至少一种与酯酶共价连接的聚合物。至少一种聚合物包括多个肟官能团。
• BIS-QUATERNARY PYRIDINIUM-ALDOYIME SALTS AND TREATMENT OF EXPOSURE TO CHOLINESTERASE INHIBITORS
  申请人：SOUTHWEST RESEARCH INSTITUTE

  公开号：EP2278967A1

  公开（公告）日：2011-02-02
• TWO PHASE BIOACTIVE FORMULATIONS
  申请人：SOUTHWEST RESEARCH INSTITUTE

  公开号：EP2323984A1

  公开（公告）日：2011-05-25
• Nanoparticles For Drug Delivery To The Central Nervous System
  申请人：MCDONOUGH Joseph A.

  公开号：US20110195125A1

  公开（公告）日：2011-08-11

  The present disclosure relates to compositions and methods for producing nanoparticles to provide relatively more rapid delivery of such particles across the blood-brain barrier. The nanoparticles may be formed from bis-quaternary pyridinium-aldoxime salts that may also be of a specific polymorphic structure and which may be formed in either hydrophobic or hydrophilic type liquid media. In addition, the nanoparticle for transport across the blood-brain barrier may comprise a polymeric resin encapsulating a bis-quaternary pyridinium-2-aldoxime salt of the formula: