tert-butyl 4-(3-aminophenyl)pyridin-2-ylcarbamate | 823215-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl 4-(3-aminophenyl)pyridin-2-ylcarbamate
• 英文别名: tert-Butyl [4-(3-aminophenyl)pyridin-2-yl]carbamate；tert-butyl N-[4-(3-aminophenyl)pyridin-2-yl]carbamate
• CAS: 823215-68-5
• 化学式: C₁₆H₁₉N₃O₂
• 分子量: 285.346
• InChiKey: VWMAGGCUKSBIBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  77.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS
  申请人：Combs Andrew Paul

  公开号：US20090286778A1

  公开（公告）日：2009-11-19

  The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及以下化学式I的大环化合物： 或其药用可接受盐或季铵盐，其中所述成员在此提供，并且它们的组成物和使用方法，这些JAK/ALK抑制剂在治疗JAK/ALK相关疾病中有用，例如炎症和自身免疫性疾病以及癌症。
• [EN] Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)<br/>[FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE CONCENTRANT LA MELANINE (MCH1R)
  申请人：BIOVITRUM AB

  公开号：WO2005051381A1

  公开（公告）日：2005-06-09

  The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  该发明涉及通式（I）的化合物，其中R0、R1、R2、R3、R4、R5、R6、R7、R8、R9、Ar和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、消旋体、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。
• [EN] NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS<br/>[FR] DERIVES DE PYRIDINE COMME INHIBITEURS SPECIFIQUES DE JNK
  申请人：ASTRAZENECA AB

  公开号：WO2005003123A1

  公开（公告）日：2005-01-13

  The present invention relates to new compounds of formula (I) wherein R is R3, R5, R6, COR5, COR6, CONHR3, CONHR5, CONHR6, CON(R6)2, COOR5, COOR6, SO2R5, SO2R6, OR3, OCOR3, COOR3, COR3, CONR3R4, NHCOR3, NR3R4, NHSO2R3, SO2R3, SO2NR3R4, SR3, CN, halogeno or NO2; R1 is aryl or heteroaryl each of which is optionally substituted with one or more of fluoro or chloro; R2 is R5, R6, COR5, COR6, CONHR5, CONHR6, CON(R6)2, COOR5, or COOR6; a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.

  本发明涉及公式（I）的新化合物，其中R是R3、R5、R6、COR5、COR6、CONHR3、CONHR5、CONHR6、CON(R6)2、COOR5、COOR6、SO2R5、SO2R6、OR3、OCOR3、COOR3、COR3、CONR3R4、NHCOR3、NR3R4、NHSO2R3、SO2R3、SO2NR3R4、SR3、CN、卤素或NO2；R1是芳基或杂环芳基，每个都可以选择性地取代一个或多个氟或氯；R2是R5、R6、COR5、COR6、CONHR5、CONHR6、CON(R6)2、COOR5或COOR6；一种制备它们的方法和其中使用的新中间体，含有这些治疗活性化合物的药物配方，以及这些活性化合物在治疗中的使用。