1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-bromoethan-1-one | 500226-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-bromoethan-1-one
• 英文别名: 1-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-bromoethanone
• CAS: 500226-07-3
• 化学式: C₁₉H₁₉BrF₂N₂O
• 分子量: 409.3
• InChiKey: GOUYYQJUGDKHMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Acyclic piperazine and piperidine derivatives
  申请人：——

  公开号：US20030191117A1

  公开（公告）日：2003-10-09

  The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

  本发明涉及无环哌嗪和哌啶衍生物，特别适用于治疗或预防与神经系统疾病相关的神经元损伤。这些化合物还适用于促进神经生长。该发明还提供了包含本发明化合物的组合物以及利用这些组合物治疗或预防神经元损伤或促进神经生长的方法。
• US6949655B2
  申请人：——

  公开号：US6949655B2

  公开（公告）日：2005-09-27
• [EN] ACYLIC PIPERAZINE AND PIPERIDINE DERIVATIVES WHICH ARE USEFUL FOR TREATING NEURONAL DAMAGE<br/>[FR] DERIVES DE PIPERAZINE ET DE PIPERIDINE ACYCLIQUES UTILES DANS LE TRAITEMENT DES TROUBLES NEURONAUX
  申请人：——

  公开号：WO2002102381A9

  公开（公告）日：2003-03-06

  [EN] The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
  [FR] L'invention concerne des dérivés de pipérazine et de pipéridine acycliques, particulièrement utiles dans le traitement ou la prévention de troubles neuronaux, notamment les troubles associés à des maladies neurologiques. Ces composés sont également utiles pour stimuler la croissance neuronale. L'invention concerne également des compositions comprenant lesdits composés, et des procédés d'utilisation de ces compositions dans le traitement ou la prévention de troubles neuronaux ou pour stimuler la croissance neuronale.