5-{1-Hydroxy-2-[2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-benzene-1,3-diol | 47308-67-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{1-Hydroxy-2-[2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-benzene-1,3-diol
• 英文别名: 5-[1-Hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]benzene-1,3-diol
• CAS: 47308-67-8
• 化学式: C₁₈H₂₃NO₄
• 分子量: 317.385
• InChiKey: WHAUNCTVVNUUIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  82
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• PREPARATION OF (R,R)-FENOTEROL AND (R,R)- OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20180141894A1

  公开（公告）日：2018-05-24

  This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.