1-(2-tert-butyl-cyclohexyl)-5-oxo-pyrrolidine-3-carboxylic acid | 1377615-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-tert-butyl-cyclohexyl)-5-oxo-pyrrolidine-3-carboxylic acid
• 英文别名: 1-(2-tert-butylcyclohexyl)-5-oxopyrrolidine-3-carboxylic acid
• CAS: 1377615-33-2
• 化学式: C₁₅H₂₅NO₃
• 分子量: 267.368
• InChiKey: DGHYVYHJJMEVGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2-isopropyl-5-methyl-cyclohexyl)-4-(pyrrolidine-1-carbonyl)-pyrrolidin-2-one 生成 1-(2-tert-butyl-cyclohexyl)-5-oxo-pyrrolidine-3-carboxylic acid 、 1-(2-tert-butyl-cyclohexyl)-4-(pyrrolidine-1-carbonyl)-pyrrolidin-2-one
  参考文献：
  名称：

  NOVEL DERIVATIVES OF 1-ALKYL-6-OXO-PIPERIDINE-3-CARBOXYLIC ACIDS AND 1-ALKYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDS AND THEIR USES AS COOLING COMPOUNDS

  摘要：

  本发明涉及由式I所表示的新型1-烷基-6-氧代哌啶-3-羧酸和1-烷基-5-氧代吡咯烷-3-羧酸衍生物，其中n是1或2的整数；R1、R2、R3和R4分别独立地选自氢和甲基组成的基团；X选自氧和氮组成的基团；R5是氢或C1-C7线性或支链脂肪烃基团，或者R5与X一起形成3-至8-成员杂环脂肪烃基团，并且它们的用途是作为冷却剂。

  公开号：

  US20120129827A1

文献信息

• Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds
  申请人：Kazimierski Arkadiusz

  公开号：US08575349B2

  公开（公告）日：2013-11-05

  The present invention relates to novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids represented by Formula I: wherein n is an integer of 1 or 2; R1, R2, R3, and R4 are each independently selected from the group consisting of hydrogen and methyl; X is selected from the group consisting of oxygen and nitrogen; and R5 is hydrogen or a C1-C7 linear or branched acyclic hydrocarbon group, or R5 together with X form a 3- to 8-membered heterocyclic hydrocarbon group, and their uses as cooling compounds.

  本发明涉及由式I所表示的1-烷基-6-氧代哌啶-3-羧酸和1-烷基-5-氧代吡咯烷-3-羧酸的新衍生物，其中n是1或2的整数；R1、R2、R3和R4各自独立地选自氢和甲基所组成的基团；X选自氧和氮所组成的基团；R5是氢或C1-C7线性或支链无环烃基，或R5与X共同形成3-至8-成员的杂环烃基，并且它们作为冷却剂的用途。
• US8575349B2
  申请人：——

  公开号：US8575349B2

  公开（公告）日：2013-11-05
• NOVEL DERIVATIVES OF 1-ALKYL-6-OXO-PIPERIDINE-3-CARBOXYLIC ACIDS AND 1-ALKYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDS AND THEIR USES AS COOLING COMPOUNDS
  申请人：Kazimierski Arkadiusz

  公开号：US20120129827A1

  公开（公告）日：2012-05-24

  The present invention relates to novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids represented by Formula I: wherein n is an integer of 1 or 2; R 1 , R 2 , R 3 , and R 4 are each independently selected from the group consisting of hydrogen and methyl; X is selected from the group consisting of oxygen and nitrogen; and R 5 is hydrogen or a C 1 -C 7 linear or branched acyclic hydrocarbon group, or R 5 together with X form a 3- to 8-membered heterocyclic hydrocarbon group, and their uses as cooling compounds.

  本发明涉及由式I所表示的新型1-烷基-6-氧代哌啶-3-羧酸和1-烷基-5-氧代吡咯烷-3-羧酸衍生物，其中n是1或2的整数；R1、R2、R3和R4分别独立地选自氢和甲基组成的基团；X选自氧和氮组成的基团；R5是氢或C1-C7线性或支链脂肪烃基团，或者R5与X一起形成3-至8-成员杂环脂肪烃基团，并且它们的用途是作为冷却剂。