(R)-2-(pyridin-3-ylsulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one | 1182733-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (R)-2-(pyridin-3-ylsulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one
• 英文别名: (8aR)-2-pyridin-3-ylsulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
• CAS: 1182733-23-8
• 化学式: C₁₂H₁₅N₃O₃S
• 分子量: 281.335
• InChiKey: SMLKIJPTZPSRRL-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  79
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NITROGEN-CONTAINING BYCYCLIC COMPOUNDS ACTIVE ON CHRONIC PAIN CONDITIONS
  申请人：Ghelardini Carla

  公开号：US20110015200A1

  公开（公告）日：2011-01-20

  The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, C 1-6 alkyl, aryl, CF 3 ; Y is CH 2 , C═O; X is bond, C═O, SO 2 , or C═N—CN; m is 0, 1; n is 0, 1; A is a heterocycle, or a phenyl group optionally substituted as defined in the specification. The compounds are active on chronic pain conditions of different origin; they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient.

  该发明涉及一般式（I）的化合物，其中R基独立地为H，C1-6烷基，芳基，CF3；Y为CH2，C═O；X为键，C═O，SO2或C═N—CN；m为0，1；n为0，1；A为杂环或苯基，可选地取代如说明书所定义。这些化合物对不同起源的慢性疼痛症状具有活性，它们可以单独或与其他药物一起使用。其中大多数化合物都是新的。该发明包括一种制备上述化合物的方法以及适用于其向患者的管理的制药组合物。
• Nitrogen-containing bicyclic compounds active on chronic pain conditions
  申请人：Neurotune AG

  公开号：EP2098526A1

  公开（公告）日：2009-09-09

  The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, C1-6alkyl, aryl, CF3; Y is CH2, C=O; X is bond, C=O, SO2, or C=N-CN; m is 0, 1; n is 0, 1; A is a heterocycle, or a phenyl group optionally substituted. The compounds are active on chronic pain conditions of different origin; they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient.

  本发明涉及通式 (I) 的化合物 其中 R 基团独立地为 H、C1-6 烷基、芳基、CF3；Y 为 CH2、C=O； X 是键、C=O、SO2 或 C=N-CN；m 是 0、1；n 是 0、1；A 是杂环或任选取代的苯基。这些化合物对不同原因引起的慢性疼痛具有疗效；它们可以单独使用，也可以与其他药物一起使用。这些化合物大多是新化合物。本发明包括制备上述化合物的工艺，以及适合患者服用的药物组合物。
• US8334286B2
  申请人：——

  公开号：US8334286B2

  公开（公告）日：2012-12-18
• [EN] NITROGEN-CONTAINING BYCYCLIC COMPOUNDS ACTIVE ON CHRONIC PAIN CONDITIONS<br/>[FR] COMPOSÉS BICYCLIQUES CONTENANT DE L'AZOTE AGISSANT SUR LES ÉTATS DE DOULEUR CHRONIQUE
  申请人：NEUROTUNE AG

  公开号：WO2009103176A1

  公开（公告）日：2009-08-27

  The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, C1-6alkyl, aryl, CF3; Y is CH2, C=O; X is bond, C=O, SO2, or C=N-CN; m is 0, 1; n is 0, 1; A is a heterocycle, or a phenyl group optionally substituted as defined in the specification. The compounds are active on chronic pain conditions of different origin; they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient.