α-Methyl-α-(4-chlor-phenyl)-bernsteinsaeure-amidnitril | 91066-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-Methyl-α-(4-chlor-phenyl)-bernsteinsaeure-amidnitril
• 英文别名: 4-Chloro-I+/--(cyanomethyl)-I+/--methylbenzeneacetamide；2-(4-chlorophenyl)-3-cyano-2-methylpropanamide
• CAS: 91066-19-2
• 化学式: C₁₁H₁₁ClN₂O
• 分子量: 222.674
• InChiKey: GPRUVCHKSASEBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• AKT PROTEIN KINASE INHIBITORS
  申请人：Array Biopharma, Inc.

  公开号：EP1684694A2

  公开（公告）日：2006-08-02
• [EN] AKT PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTEINE KINASE AKT
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2005051304A2

  公开（公告）日：2005-06-09

  The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.