N-<1(R)-(2-pyridyl)ethyl>-1(S)-phenylethylamine | 95447-96-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-<1(R)-(2-pyridyl)ethyl>-1(S)-phenylethylamine
• 英文别名: (S)-1-phenyl-N-[(R)-1-(pyridin-2-yl)ethyl]ethanamine；(1S)-1-phenyl-N-[(1R)-1-pyridin-2-ylethyl]ethanamine
• CAS: 95447-96-4
• 化学式: C₁₅H₁₈N₂
• 分子量: 226.321
• InChiKey: FLHJEJWJIZRYOL-QWHCGFSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 N-<1(R)-(2-pyridyl)ethyl>-1(S)-phenylethylamine 以 水 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到
  参考文献：
  名称：

  Synthesis and in vitro antitumour activity of PtCl2 complexes of pyridine- and quinoline-amine and -imine ligands and of carbocyclic ethylenediamine ligands

  摘要：

  DOI：

  10.1016/s0020-1693(00)85674-1
• 作为产物：
  描述：

  (S)-α-Methyl-N-<1-(2-pyridinyl)ethyliden>phenylmethanamin 生成 N-<1(R)-(2-pyridyl)ethyl>-1(S)-phenylethylamine
  参考文献：
  名称：

  ELEVELD, M. B.;HOGEVEEN, H., TETRAHEDRON LETT., 1984, 25, N 45, 5187-5190

  摘要：

  DOI：

文献信息

• Diastereoselective addition of methyllithium and dimethylcuprate-boron trifluoride to imines derived from (S)-1-phenylethylamine
  作者：Giuseppe Alvaro、Diego Savoia、Maria R. Valentinetti

  DOI：10.1016/0040-4020(96)00746-6

  日期：1996.9

  trifluoride reagents with the imines derived from (S)-1-phenylethylamine afforded the secondary amines by addition to the Si face of the imines. (S,S)-bis(1-phenylethyl)amine and (S)-1-cyclohexylethanamine were prepared with high stereoselectivity, in the latter case by a two step sequence involving the final cleavage of the auxiliary. Methyllithium attacked mainly the Si face of the imines derived from 4-pyridine

  通过将二甲基铜酸酯-三氟化硼试剂与衍生自（S）-1-苯基乙胺的亚胺反应，可通过向亚胺的Si表面添加仲胺得到仲胺。（S，S）-双（1-苯乙基）胺和（S）-1-环己基六胺以高的立体选择性制备，在后一种情况下，通过涉及最终裂解助剂的两步顺序制备。甲基锂主要攻击由4-吡啶羧醛和2-甲氧基苯甲醛衍生的亚胺的Si面，但对由2-吡啶和2-呋喃羧醛衍生的亚胺的Re面具有侵蚀作用。
• Zinc complexes bearing N,N′-bidentate entiopure ligands: Synthesis, structure and catalytic activity toward ring opening polymerisation of rac-lactide
  作者：Saira Nayab、Hyosun Lee、Jong Hwa Jeong

  DOI：10.1016/j.poly.2012.05.044

  日期：2012.8

  Dichloro zinc complexes with (S)-1-phenyl-N-[(S)-1-(pyridin-2-yl)ethyl]ethanamine (PMMA) and (S)-[(6-methylpyridin-2-yl)-N-RS)-1-phenylethyl]ethanamine (MPMMA) were prepared and characterised by X-ray diffraction. The catalytic activity of the dimethyl complexes, generated in situ, was high in the ring opening polymerization of rac-lactide. Specifically, the dimethyl derivative of (PMMA)ZnCl2 yielded a highly stereocontrolled polylactide with P-r = 0.84. (C) 2012 Elsevier Ltd. All rights reserved.
• Diastereoselective synthesis of chiral secondary amines with two chiral centers directly attached to the nitrogen atom
  作者：M. B. Eleveld、H. Hogeveen、E. P. Schudde

  DOI：10.1021/jo00369a016

  日期：1986.9
• Enantioselective addition of n-butyllithium to benzaldehyde in the presence of chiral lithium amides
  作者：M.B. Eleveld、H. Hogeveen

  DOI：10.1016/s0040-4039(01)81559-8

  日期：1984.1
• ELEVELD M. B.; HOGEVEEN H.; SCHUDDE E. P., J. ORG. CHEM., 51,(1986) N 19, 3635-3642
  作者：ELEVELD M. B.、 HOGEVEEN H.、 SCHUDDE E. P.

  DOI：——

  日期：——