3,3-Difluoro-1-[(4-nitrophenyl)methyl]pyrrolidine | 1093095-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-Difluoro-1-[(4-nitrophenyl)methyl]pyrrolidine
• CAS: 1093095-03-4
• 化学式: C₁₁H₁₂F₂N₂O₂
• 分子量: 242.225
• InChiKey: BFMPKZAYMBZNDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• INDOLINE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER
  申请人：Treu Matthias

  公开号：US20100184747A1

  公开（公告）日：2010-07-22

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 4 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.