(2,6-Dimethoxy-4-methyl-phenyl)-(2,4-dimethoxy-phenyl)-methanone | 247086-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,6-Dimethoxy-4-methyl-phenyl)-(2,4-dimethoxy-phenyl)-methanone
• CAS: 247086-80-2
• 化学式: C₁₈H₂₀O₅
• 分子量: 316.354
• InChiKey: OTZASDLEDLZBSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.26
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  53.99
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (2,6-Dimethoxy-4-methyl-phenyl)-(2,4-dimethoxy-phenyl)-methanone 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以64%的产率得到(2,6-Dihydroxy-4-methyl-phenyl)-(4-hydroxy-2-methoxy-phenyl)-methanone
  参考文献：
  名称：

  Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

  摘要：

  Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00305-4
• 作为产物：
  描述：

  2,4-二甲氧基苯甲酸 在 正丁基锂 、 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 生成 (2,6-Dimethoxy-4-methyl-phenyl)-(2,4-dimethoxy-phenyl)-methanone
  参考文献：
  名称：

  Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

  摘要：

  Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00305-4