3-((R)-4-benzyl-2-oxooxazolidin-3-yl)benzoic acid | 537657-99-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((R)-4-benzyl-2-oxooxazolidin-3-yl)benzoic acid
• 英文别名: 3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]benzoic acid
• CAS: 537657-99-1
• 化学式: C₁₇H₁₅NO₄
• 分子量: 297.3
• InChiKey: UTAQENCMOPRKMF-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-(2-oxopyrrolidin-1-yl)-5-phenylbenzamide 、 3-((R)-4-benzyl-2-oxooxazolidin-3-yl)benzoic acid 、 (2R,4S,5S)-5-amino-N-bicyclo[2.2.1]hept-2-yl-4-hydroxy-2-methyl-6-phenylhexanamide 生成 N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)benzamide
  参考文献：
  名称：

  Benzamide derivatives, processes for their preparation, and their pharmaceutical use

  摘要：

  本发明涉及一种新型羟基乙烯化合物，具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性，其制备过程，包含它们的组合物以及它们在治疗β-淀粉样蛋白水平或β-淀粉样蛋白沉积物升高的疾病，特别是阿尔茨海默病中的使用。

  公开号：

  US06992103B2

文献信息

• BENZAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1448520A1

  公开（公告）日：2004-08-25
• US6992103B2
  申请人：——

  公开号：US6992103B2

  公开（公告）日：2006-01-31
• [EN] BENZAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE<br/>[FR] DERIVES DE BENZAMIDE, PROCEDES DE PREPARATION ASSOCIES ET UTILISATION PHARMACEUTIQUE DESDITS DERIVES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003045913A1

  公开（公告）日：2003-06-05

  The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β - amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
• Benzamide derivatives, processes for their preparation, and their pharmaceutical use
  申请人：Faller Andrew

  公开号：US20050085520A1

  公开（公告）日：2005-04-21

  The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.

  本发明涉及一种新型的羟基乙烯化合物，具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性，其制备过程，包含它们的组合物以及它们在治疗β-淀粉样蛋白水平或β-淀粉样蛋白沉积物升高的疾病，特别是阿尔茨海默病中的用途。