2-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-1,2,5,6-tetrahydro- | 1823815-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-1,2,5,6-tetrahydro-
• 英文别名: 2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-6-yl]acetic acid
• CAS: 1823815-56-0
• 化学式: C₁₂H₁₉NO₄
• 分子量: 241.28
• InChiKey: ULRIBLKDCSQNCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Metabolites of tricyclic amides useful for inhibition of G-protein function and methods of treatment of proliferative diseases
  申请人：Schering Corporation

  公开号：US20040266810A1

  公开（公告）日：2004-12-30

  The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I): 1 and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I), wherein: R 1 is selected from the group consisting of H and ═O; R 2 -R 5 can be the same or different, each being independently selected from the group consisting of H, —OH, halide, —NH 2 and ═O; and, the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when, the double bonds are not adjacent, and when 0, one of R 1 -R 5 is not H. Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds.

  本发明涉及三环酰胺代谢物和结构相关化合物，其表示为结构式（I）： 其中：R1选自H和═O组成的群；R2-R5可以相同或不同，每个独立地选自H，—OH，卤素，—NH2和═O组成的群；以及组合的实虚线独立地表示单键或双键，其中双键的组合实虚线数不大于2，且当双键不相邻时，当0时，R1-R5中的一个不是H。 还公开了使用这些新化合物的方法，包括治疗增殖性疾病的方法，抑制细胞异常生长的方法，以及抑制法尼酰丝氨酸蛋白转移酶的方法。这些化合物的制剂也在本发明中公开。
• METABOLITES OF TRICYCLIC AMIDES USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND METHODS OF TREATMENT OF PROLIFERATIVE DISEASES
  申请人：SCHERING CORPORATION

  公开号：EP1644359A2

  公开（公告）日：2006-04-12
• US7271174B2
  申请人：——

  公开号：US7271174B2

  公开（公告）日：2007-09-18
• [EN] METABOLITES OF TRICYCLIC AMIDES USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND METHODS OF TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] METABOLITES D'AMIDES TRICYCLIQUES SERVANT A INHIBER LA FONCTION DE PROTEINES G ET PROCEDES DE TRAITEMENT DE MALADIES PROLIFERATIVES
  申请人：SCHERING CORP

  公开号：WO2005003120A2

  公开（公告）日：2005-01-13

  The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I) and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I), wherein: R1 is selected from the group consisting of H and =O; R2-R5 can be the same or different, each being independently selected from the group consisting of H, -OH, halide, -NH2 and =O; and, the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when 2, the double bonds are not adjacent, and when 0, one of R1-R5 is not H. Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds.