24-β-Hydroxycholesterol | 474-73-7

• 物质功能分类: 医药中间体 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-β-Hydroxycholesterol
• 英文别名: (3S,10R,13R,17R)-17-[(5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 474-73-7；27460-26-0；28842-86-6；30271-38-6；80656-36-6
• 化学式: C₂₇H₄₆O₂
• 分子量: 402.661
• InChiKey: IOWMKBFJCNLRTC-ONJKWJGFSA-N

物化性质

• 沸点：
  513.1±23.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

24-Hydroxycholesterol 是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂。

体外研究

24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation.

体内研究

Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1 ⁺ islets. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain.

文献信息

• Hydroxycholesterol immunoassay
  申请人：ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC.

  公开号：US10197583B2

  公开（公告）日：2019-02-05

  Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective.

  本研究提供了一种 22-羟基胆固醇、24S-羟基胆固醇、25-羟基胆固醇、26-羟基胆固醇或 27-羟基胆固醇的衍生物。还提供了与上述衍生物共轭的蛋白质。还提供了一种抗体组合物，其中包含与 22-羟基胆固醇、24S-羟基胆固醇、25-羟基胆固醇、26-羟基胆固醇或 27-羟基胆固醇特异性结合的抗体。此外，还提供了一种制造特异性结合 22-羟基胆固醇、24S-羟基胆固醇、25-羟基胆固醇、26-羟基胆固醇或 27-羟基胆固醇的抗体的方法。还提供了一种检测 22-羟基胆固醇、24S-羟基胆固醇、25-羟基胆固醇、26-羟基胆固醇或 27-羟基胆固醇的方法。此外，还提供了一种检测 22-羟基胆固醇、24S-羟基胆固醇、25-羟基胆固醇、26-羟基胆固醇或 27-羟基胆固醇的试剂盒。还提供了一种检测药物二期代谢中使用的一种或多种酶的方法。此外，还提供了一种检测合成 22-羟基胆固醇、24S-羟基胆固醇、25-羟基胆固醇、26-羟基胆固醇或 27-羟基胆固醇的酶的方法。还提供了一种评估患者多发性硬化症进展的方法。还提供了一种确定治疗患者多发性硬化症是否有效的方法。此外，还提供了一种评估患者亨廷顿氏病进展情况的方法。此外，还提供了一种确定治疗患者亨廷顿氏病是否有效的方法。
• HYDROXYCHOLESTEROL IMMUNOASSAY
  申请人：Mullenix Michael C.

  公开号：US20120115169A1

  公开（公告）日：2012-05-10

  Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective.
• US8969525B2
  申请人：——

  公开号：US8969525B2

  公开（公告）日：2015-03-03