(3-{2-[(benzyl-cyclopropanecarbonyl-amino)-methyl]-quinolin-3-yl}-4-methoxy-phenyl)-acetic acid | 1219696-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (3-{2-[(benzyl-cyclopropanecarbonyl-amino)-methyl]-quinolin-3-yl}-4-methoxy-phenyl)-acetic acid
• 英文别名: 2-[3-[2-[[Benzyl(cyclopropanecarbonyl)amino]methyl]quinolin-3-yl]-4-methoxyphenyl]acetic acid
• CAS: 1219696-57-7
• 化学式: C₃₀H₂₈N₂O₄
• 分子量: 480.563
• InChiKey: KRCZYDCOPNYEOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NEUTRAL LXR MODULATORS<br/>[FR] MODULATEURS DE LXR NEUTRES
  申请人：PHENEX FXR GMBH

  公开号：WO2020148325A1

  公开（公告）日：2020-07-23

  The present invention relates to amine, carboxamide or thioamide containing compounds which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR. The compounds are of formula (I) wherein rings A-D, substituents R1-R6 and X and m and n are as defined in the application.

  本发明涉及含有胺基、羧酰胺或硫代酰胺的化合物，这些化合物与肝X受体（LXRα和/或LXRβ）结合，并且在作为LXR的反向激动剂时表现出优势。这些化合物的分子式为（I），其中环A-D、取代基R1-R6、以及X、m和n的定义如申请中所述。
• HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：Hutchinson John Howard

  公开号：US20110319445A1

  公开（公告）日：2011-12-29

  Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

  本文描述了异杂环化合物，它们是PGD2受体的拮抗剂。还描述了包括所述异杂环化合物的制药组合物和药物。本文还描述了使用这种PGD2受体拮抗剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他PGD2依赖或PGD2介导的疾病或病症。
• AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS
  申请人：Phenex-FXR GmbH

  公开号：US20200131144A1

  公开（公告）日：2020-04-30

  The present invention relates to derivatives of formula (I) which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR.
• US8378107B2
  申请人：——

  公开号：US8378107B2

  公开（公告）日：2013-02-19
• [EN] HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS<br/>[FR] ANTAGONISTES D'HÉTÉROARYLE DES RÉCEPTEURS DE LA PROSTAGLANDINE D2
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2010039977A2

  公开（公告）日：2010-04-08

  Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.