N-(1,3,4-Tris(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea | 1450719-64-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: N-(1,3,4-Tris(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea
• 英文别名: 1,3-bis(hydroxymethyl)-1-[1,3,4-tris(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea
• CAS: 1450719-64-8
• 化学式: C₉H₁₆N₄O₈
• 分子量: 308.25
• InChiKey: BEEHUIXXNCWWPG-UHFFFAOYSA-N

物化性质

• 密度：
  1.86±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Reduction of antimicrobial compound levels during product dispensing
  申请人：Rohm and Haas Company

  公开号：EP2243516A1

  公开（公告）日：2010-10-27

  A method for reducing antimicrobial compound levels in a liquid composition containing at least one antimicrobial compound. The method comprises contacting said liquid composition with a functionalized resin. Antimicrobial compounds that may be removed by this method include isothiazolin-3-ones, e.g., 2-methyl-4-isothiazolin-3-one; 5-chloro-2-methyl-4-isothiazolin-3-one; 2-n-octyl-4-isothiazolin-3-one; 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; 1,2-benzisothiazolin-3-one and N-alkyl derivatives thereof, especially N-methyl and N-n-butyl; 2, 2-dibromo-3-nitrilopropionamide (DBNPA); 2-bromo-2-nitropropanediol (BNPD); dithio-2,2'-bis(benzmethylamide) (DTBMA); hexetidine; chlorphenesin, C1-C4 alkyl-4-hydroxybenzoates (alkyl parabens); 3-iodopropynylbutylcarbamate (IPBC); formaldehyde releasers and mixtures thereof.

  一种降低含有至少一种抗菌化合物的液体组合物中抗菌化合物含量的方法。该方法包括将所述液体组合物与官能化树脂接触。该方法可去除的抗菌化合物包括异噻唑啉-3-酮，例如2-甲基-4-异噻唑啉-3-酮；5-氯-2-甲基-4-异噻唑啉-3-酮；2-正辛基-4-异噻唑啉-3-酮；4,5-二氯-2-正辛基-4-异噻唑啉-3-酮；1,2-苯并异噻唑啉-3-酮及其 N-烷基衍生物，特别是 N-甲基和 N-正丁基；2,2-二溴-3-硝基丙酰胺 (DBNPA)；2-溴-2-硝基丙二醇 (BNPD)；二硫-2,2'-双苯甲酰胺 (DTBMA)；己定；氯苯甘醚；C1-C4 烷基-4-羟基苯甲酸酯（对羟基苯甲酸烷基酯）；3-碘丙炔基丁基氨基甲酸酯 (IPBC)；甲醛释放剂及其混合物。
• Process and kit for treating hair
  申请人：Colomer Beauty and Professional Products, S.L.

  公开号：EP2422763A1

  公开（公告）日：2012-02-29

  A process for improving, among other properties, the resistance of hair to break and a kit specially adapted to carry out such process.

  一种用于改善头发抗折断能力等特性的工艺，以及一种专门用于实施该工艺的工具包。
• Phenol derivatives as antimicrobial agents
  申请人：Symrise AG

  公开号：EP2606725A1

  公开（公告）日：2013-06-26

  The invention relates to the use of (i) a compound of formula (I) or a (pharmaceutically) acceptable salt thereof or (ii) a mixture comprising one or more or consisting of two or more compounds of formula (I) and/or said salts wherein R1 denotes a radical in ortho-, meta, or para-position to the phenolic OH group, the radical being selected from the group consisting of E/Z-3-methylbut-l-en-1-yl, 3-methylbut-2-en-1-yl and 3-methylbut-3-en-1-yl and R2 denotes a radical in ortho-, meta, or para-position to the phenolic OH group, the radical being selected from the group consisting of H and alkyl groups with 1 to 3 C atoms as antimicrobial agent for inactivation of microorganisms, in particular for rapid inactivation of microorganisms, with the proviso that the use is not within a method for treatment of the human or animal body by surgery or therapy or within a diagnostic method practised on the human or animal body.

  本发明涉及以下物质的用途：(i) 式 (I) 化合物或其 (药学上) 可接受的盐，或 (ii) 由一种或多种或由两种或多种式 (I) 化合物和/或所述盐组成的混合物 其中 R1 表示与酚羟基处于正位、偏位或对位的基团，该基团选自由 E/Z-3-甲基丁-l-烯-1-基、3-甲基丁-2-烯-1-基和 3-甲基丁-3-烯-1-基组成的组，R2 表示与酚羟基处于正位、偏位或对位的基团，该基团选自由 E/Z-3-甲基丁-l-烯-1-基、3-甲基丁-2-烯-1-基和 3-甲基丁-3-烯-1-基组成的组、这些基团选自 H 和具有 1 至 3 个 C 原子的烷基组成的基团组，用作灭活微生物的抗菌剂，特别是用于快速灭活微生物，但该用途不得用于通过手术或治疗对人体或动物体进行治疗的方法中，也不得用于对人体或动物体进行诊断的方法中。
• Antimicrobial compositions
  申请人：Symrise AG

  公开号：EP2774481A1

  公开（公告）日：2014-09-10

  Suggested is a antimicrobial agent comprising at least one acetophenone derivative of formula (I) in which R1 stands for hydrogen or methyl, and R2 stands for hydrogen, hydroxyl or a -OCH3 group, or a cosmetically or pharmaceutically acceptable salt thereof.

  建议的抗菌剂包含至少一种式 (I) 的苯乙酮衍生物 其中 R1 代表氢或甲基，以及 R2 代表氢、羟基或 -OCH3 基团、 或其美容或制药上可接受的盐。
• Methods of cancer treatment
  申请人：K-Gen, Inc.

  公开号：US10722484B2

  公开（公告）日：2020-07-28

  This present disclosure is directed to a method of treating a subject with cancer with a combination of a protein kinase C (PKC) activator and a second therapeutic agent.

  本公开涉及一种用蛋白激酶 C (PKC) 激活剂和第二种治疗剂组合治疗癌症患者的方法。