HO Peg scm,MW 2K | 196936-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: HO Peg scm,MW 2K
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 2-(2-hydroxyethoxy)acetate
• CAS: 196936-11-5
• 化学式: C₈H₁₁NO₆
• 分子量: 217.18
• InChiKey: ZQFNBHVVRRYZBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• BIODEGRADABLE BLOCK POLYMERS FOR DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：Hedrick James

  公开号：US20110152167A1

  公开（公告）日：2011-06-23

  A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of urea groups, a carboxylic acid groups, and mixtures thereof. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.

  一种可生物降解的嵌段共聚物被披露，包括源自聚醚醇的亲水性块；和包括由聚醚醇引发的第一环状羰基单体的环开聚合得到的疏水性块，该第一重复单元包括一个侧链基团，该侧链基团包括从尿素基团、羧酸基团或它们的混合物中选择的功能基团。疏水性块的任何侧链均不包括共价结合的生物活性物质。该嵌段共聚物在水中自组装形成适合通过非共价相互作用固定生物活性物质的胶束，并且根据ASTM D6400标准，该嵌段共聚物在180天内生物降解60%。
• POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20160022828A1

  公开（公告）日：2016-01-28

  The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

  本发明提供了通过共价结合水溶性寡聚体进行化学修饰的肽。本发明的结合物在通过任何一种给药途径进行给药时，表现出与未附着水溶性寡聚体的肽不同的特征。
• IMPLANTABLE BIOREACTOR FOR DELIVERY OF PARACRINE FACTORS
  申请人：Gerstenblith Gary

  公开号：US20120083767A1

  公开（公告）日：2012-04-05

  An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.
• MODIFIED RECOMBINANT FACTOR VIII AND VON WILLEBRAND FACTOR AND METHODS OF USE
  申请人：Schwarz Hans-Peter

  公开号：US20120322737A1

  公开（公告）日：2012-12-20

  The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.
• CONJUGATES OF A GM-CSF MOIETY AND A POLYMER
  申请人：NEKTAR THERAPEUTICS

  公开号：US20140044672A1

  公开（公告）日：2014-02-13

  Conjugates of a GM-CSF moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.