2-{(E)-2-[(2-cyclopentyloxy-3-methoxy)phenyl]vinyl}-3-(4-trifluoromethoxy)phenyl-4H-pyrido[1,2-α]pyrimidin-4-one | 1186486-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-{(E)-2-[(2-cyclopentyloxy-3-methoxy)phenyl]vinyl}-3-(4-trifluoromethoxy)phenyl-4H-pyrido[1,2-α]pyrimidin-4-one
• 英文别名: 2-[(E)-2-(2-cyclopentyloxy-3-methoxyphenyl)ethenyl]-3-[4-(trifluoromethoxy)phenyl]pyrido[1,2-a]pyrimidin-4-one
• CAS: 1186486-91-8
• 化学式: C₂₉H₂₅F₃N₂O₄
• 分子量: 522.524
• InChiKey: RZLODDXHTYXNGP-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Fused Pyrimidine Derivatives as Trpv3 Modulators
  申请人：Lingam V S, Prasadarao

  公开号：US20100292254A1

  公开（公告）日：2010-11-18

  The present invention related to fused pyrimidine derivatives, which are useful as Transient Receptor Potential Vanilloid 3 (TRPV3) receptors, methods of treating deseases, disorders, conditions modulated by TRPV3. The present invention having the formula (I) and its pharmaceutically acceptable salts thereof, and its processes thereof, wherein all variables are as described herein.

  本发明涉及熔合嘧啶衍生物，其可用作瞬时受体电位香草酸3（TRPV3）受体，用于治疗由TRPV3调节的疾病，疾病和状况的方法。本发明具有公式（I）及其药学上可接受的盐及其过程，其中所有变量如本文所述。
• US8349846B2
  申请人：——

  公开号：US8349846B2

  公开（公告）日：2013-01-08
• [EN] FUSED PYRIMIDINE DERIVATIVES AS TRPV3 MODULATORS<br/>[FR] DÉRIVÉS DE PYRIMIDINE CONDENSÉE EN TANT QUE MODULATEURS DE TRPV3
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2009109987A2

  公开（公告）日：2009-09-11

  The present invention related to fused pyrimidine derivatives, which are useful as Transient Receptor Potential Vanilloid 3 (TRPV3) receptors, methods of treating deseases, disorders, conditions modulated by TRPV3. The present invention having the formula (I) and its pharmaceutically acceptable salts thereof, and its processes thereof, wherein all variables are as described herein.