3a(2)-Chloro-4a(2)-fluoro-6-methoxy[1,1a(2)-biphenyl]-3-ethanamine | 1181295-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3a(2)-Chloro-4a(2)-fluoro-6-methoxy[1,1a(2)-biphenyl]-3-ethanamine
• 英文别名: 2-[3-(3-chloro-4-fluorophenyl)-4-methoxyphenyl]ethanamine
• CAS: 1181295-52-2
• 化学式: C₁₅H₁₅ClFNO
• 分子量: 279.73
• InChiKey: WDYIYYAHMGELEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Aryl and heteroaryl compounds, compositions, and methods of use
  申请人：Mjalli M.M. Adnan

  公开号：US20050059713A1

  公开（公告）日：2005-03-17

  This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.

  本发明提供了公式(I)所描述的芳基和杂环芳基化合物，以及它们的制备方法。还提供了由公式(I)化合物制成的制药组合物和制备这种组合物的方法。公式(I)化合物可能有助于治疗包括正痘病毒在内的病毒感染，可以单独使用或与其他治疗剂联合使用。
• US7459472B2
  申请人：——

  公开号：US7459472B2

  公开（公告）日：2008-12-02
• [EN] ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSES ARYLE ET HETEROARYLE, COMPOSITIONS, ET METHODES D'UTILISATION
  申请人：TRANSTECH PHARMA INC

  公开号：WO2005014534A1

  公开（公告）日：2005-02-17

  This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.