(3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone | 851958-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone
• 英文别名: (3-Ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone；(3-ethoxy-4-methoxyphenyl)-(3-pyrrol-1-ylphenyl)methanone
• CAS: 851958-51-5
• 化学式: C₂₀H₁₉NO₃
• 分子量: 321.376
• InChiKey: OVTPDLHLHWIHNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  40.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanol 在 二氧化锰 作用下， 以 二氯甲烷 为溶剂， 反应 34.0h， 以gave (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone as a brown oil (1.58 g, 85% crude yield 2 steps)的产率得到(3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone
  参考文献：
  名称：

  Diphenylethylene compounds and uses thereof

  摘要：

  本发明涉及二苯乙烯类化合物和包含二苯乙烯类化合物的组合物。本发明还涉及通过向需要治疗的受体中施用一个或多个二苯乙烯类化合物来预防或治疗各种疾病和疾病。特别是，本发明涉及通过向需要治疗的受体中施用一个或多个二苯乙烯类化合物来预防或治疗癌症或炎症性疾病的方法。本发明还涉及包含一个或多个二苯乙烯类化合物的制品和套件。

  公开号：

  US07470723B2

文献信息

• DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF
  申请人：CELGENE CORPORATION

  公开号：EP1799634A2

  公开（公告）日：2007-06-27
• US7470723B2
  申请人：——

  公开号：US7470723B2

  公开（公告）日：2008-12-30
• [EN] DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES DE DIPHENYLETHYLENE ET LEURS UTILISATIONS
  申请人：CELGENE CORP

  公开号：WO2006026747A2

  公开（公告）日：2006-03-09

  The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.
• Diphenylethylene compounds and uses thereof
  申请人：Muller W. George

  公开号：US20050107339A1

  公开（公告）日：2005-05-19

  The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

  本发明涉及二苯乙烯化合物和包含二苯乙烯化合物的组合物。本发明还涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗各种疾病和紊乱的方法。具体而言，该发明涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗癌症或炎症性紊乱的方法。本发明还涉及包含一种或多种二苯乙烯化合物的制品和工具包。