2-(3-Methyl-2-oxopyridin-1(2H)-yl)benzoic acid | 674798-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Methyl-2-oxopyridin-1(2H)-yl)benzoic acid
• 英文别名: 2-(3-methyl-2-oxopyridin-1-yl)benzoic acid
• CAS: 674798-43-7
• 化学式: C₁₃H₁₁NO₃
• 分子量: 229.23
• InChiKey: PGNNMIGQXWUNFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• STABILE CREME-ZUBEREITUNGEN VON PHENYL-PYRIDONVERBINDUNGEN FÜR TOPISCHE ANWENDUNG
  申请人：Mepha AG

  公开号：EP1539155B1

  公开（公告）日：2008-04-02
• Stable cream preparations of phenyl-pyridone compounds for topical application
  申请人：Scheiwe Werner Max

  公开号：US20060039931A1

  公开（公告）日：2006-02-23

  The invention relates to a pharmaceutical cream preparation for topical application in the form of an oil-in-water (o/w) emulsion, containing the following constituents in the lipophilic phase: (i) an optionally substituted 1-phenyl-2-(1H)-pyridone compound or a pharmaceutically acceptable salt thereof, as an active ingredient, (ii) at least one surface-active solubilising agent having an HLB value between 15 and 20, (iii) at least one emulsifier having an HLB value between 8 and 15, and (iv) optionally other carrier materials and additives known per se selected from the group containing triglycerides, penetration amplifiers, preserving agents and anti-oxidants. The invention also relates to the use of the preparation as a topical cream preparation for the treatment or prophylaxis of skin diseases.