5-acetyl-3-(4-fluoro-phenylthio)-4-methyl-1H-pyridine-2-one | 918542-62-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-acetyl-3-(4-fluoro-phenylthio)-4-methyl-1H-pyridine-2-one
• 英文别名: 5-Acetyl-3-[(4-fluorophenyl)sulfanyl]-4-methylpyridin-2(1H)-one；5-acetyl-3-(4-fluorophenyl)sulfanyl-4-methyl-1H-pyridin-2-one
• CAS: 918542-62-8
• 化学式: C₁₄H₁₂FNO₂S
• 分子量: 277.319
• InChiKey: RAWYSHGIKTYKKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-acetyl-3-(4-fluoro-phenylsulfanyl)-1-(4-methoxy-benzyl)-4-methyl-1H-pyridin-2-one 在 三氟乙酸 作用下， 反应 16.0h， 以75.5%的产率得到5-acetyl-3-(4-fluoro-phenylthio)-4-methyl-1H-pyridine-2-one
  参考文献：
  名称：

  WO2007/4543

  摘要：

  公开号：

文献信息

• PHARMACEUTICAL COMPOSITIONS CONTAINING 2-PYRIDONE DERIVATIVES AS EFFECTIVE COMPONENTS
  申请人：Kato Masatoshi

  公开号：US20090298889A1

  公开（公告）日：2009-12-03

  The present invention herein provides a 2-pyridone derivative which has a cell adhesion-inhibitory activity and which is useful for preventing and/or treating pathema or disease conditions including, for instance, inflammations which relate to leukocytic infiltration. The 2-pyridone derivative is a compound represented by the following general formula (1). In the formula, R 1 represents, for instance, a phenyl or pyridyl group, R 2 represents, for instance, a phenyl group, R 3 represents, for instance, a lower alkyl group, R 4 represents, for instance, a lower alkyl group, R 5 represents, for instance, a lower alkyl group, and R 6 represents, for instance, a lower alkyl group.

  本发明提供了一种2-吡啶酮衍生物，该衍生物具有细胞黏附抑制活性，并可用于预防和/或治疗包括与白细胞浸润有关的炎症在内的病理或疾病状况。2-吡啶酮衍生物是由以下通式（1）表示的化合物。在该式中，R1代表例如苯基或吡啶基，R2代表例如苯基，R3代表例如较低的烷基，R4代表例如较低的烷基，R5代表例如较低的烷基，R6代表例如较低的烷基。
• PHARMACEUTICAL COMPOSITION COMPRISING 2-PYRIDONE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Sato Pharmaceutical Co. Ltd.

  公开号：EP1897870A1

  公开（公告）日：2008-03-12

  The present invention herein provides a 2-pyridone derivative which has a cell adhesion-inhibitory activity and which is useful for preventing and/or treating pathema or disease conditions including, for instance, inflammations which relate to leukocytic infiltration. The 2-pyridone derivative is a compound represented by the following general formula (1). In the formula, R1 represents, for instance, a phenyl or pyridyl group, R2 represents, for instance, a phenyl group, R3 represents, for instance, a lower alkyl group, R4 represents, for instance, a lower alkyl group, R5 represents, for instance, a lower alkyl group, and R6 represents, for instance, a lower alkyl group:

  本发明提供了一种 2-吡啶酮衍生物，它具有细胞粘附抑制活性，可用于预防和/或治疗病变或疾病，包括例如与白细胞浸润有关的炎症。2 吡啶酮衍生物是由以下通式（1）表示的化合物。式中，R1 代表苯基或吡啶基，R2 代表苯基，R3 代表低级烷基，R4 代表低级烷基，R5 代表低级烷基，R6 代表低级烷基：