3-[5-[(4-Trifluoromethyl)benzyloxy]-2-indolyl]-2-phenoxypropionic acid | 209479-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[5-[(4-Trifluoromethyl)benzyloxy]-2-indolyl]-2-phenoxypropionic acid
• 英文别名: 2-phenoxy-3-[5-[[4-(trifluoromethyl)phenyl]methoxy]-1H-indol-2-yl]propanoic acid
• CAS: 209479-01-6
• 化学式: C₂₅H₂₀F₃NO₄
• 分子量: 455.433
• InChiKey: PCSVXGNNZULLTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Propionic acid derivatives
  申请人：——

  公开号：US20020032330A1

  公开（公告）日：2002-03-14

  A propionic acid derivative having the following formula (II) and its salt: 1 [wherein A 1 is an aryl or heterocyclic group which may have a substituent; Y 2 is an alkylene chain having 1 to 5 carbon atoms; X 4 is a single bond, an oxygen atom, or a sulfur atom; W 1 is a naphthalene ring, a quinoline ring, an indole ring, a benzisoxazole ring, or benzo[b]thiophene ring, all of which may have a substituent; R 4 is a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; X 5 is an oxygen atom or a sulfur atom; R 5 is an alkyl group having 1 to 8 carbon atoms, an aralkyl group, or an aryl group, all of which may have a substituent] have a hypoglycemic effect and hypolipidemic activity.

  具有以下结构式（II）及其盐的丙酸衍生物：其中A1为可能具有取代基的芳基或杂环基；Y2为具有1至5个碳原子的烷基链；X4为单键、氧原子或硫原子；W1为萘环、喹啉环、吲哚环、苯并异噁唑环或苯并噻吩环，均可能具有取代基；R4为氢原子或具有1至8个碳原子的烷基基团；X5为氧原子或硫原子；R5为具有1至8个碳原子的烷基基团、芳基烷基基团或芳基，均可能具有取代基，具有降血糖作用和降脂活性。
• PROPIONIC ACID DERIVATIVES
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0994095A1

  公开（公告）日：2000-04-19

  A propionic acid derivative having the following formula (II) and its salt: [wherein A1 is an aryl or heterocyclic group which may have a substituent; Y2 is an alkylene chain having 1 to 5 carbon atoms; X4 is a single bond, an oxygen atom, or a sulfur atom; W1 is a naphthalene ring, a quinoline ring, an indole ring, a benzisoxazole ring, or benzo[b]thiophene ring, all of which may have a substituent; R4 is a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; X5 is an oxygen atom or a sulfur atom; R5 is an alkyl group having 1 to 8 carbon atoms, an aralkyl group, or an aryl group, all of which may have a substituent] have a hypoglycemic effect and hypolipidemic activity.

  具有下式（II）的丙酸衍生物及其盐： [其中 A1 是芳基或杂环基团，可具有取代基；Y2 是具有 1 至 5 个碳原子的亚烷基链；X4 是单键、氧原子或硫原子；W1 是萘环、喹啉环、吲哚环、苯并异噁唑环或苯并[b]噻吩环，所有这些环均可具有取代基；R4 是氢原子或具有 1 至 8 个碳原子的烷基；X5 是氧原子或硫原子；R5 是具有 1 至 8 个碳原子的烷基、芳基或芳基，所有这些基团都可以具有取代基]具有降血糖作用和降血脂活性。