4-Nitrophenyl 2-oxopropanoate | 27633-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-Nitrophenyl 2-oxopropanoate
• 英文别名: (4-nitrophenyl) 2-oxopropanoate
• CAS: 27633-20-1
• 化学式: C9H7NO5
• 分子量: 209.16
• InChiKey: GESXRWPLNGTJEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] METHOD FOR PREPARING (S)-INDOLINE-2-CARBOXYLIC ACID AND (S)-INDOLINE-2-CARBOXYLIC ACID METHYL ESTER USING HYDROLYTIC ENZYME<br/>[FR] METHODE DE PREPARATION D'UN ACIDE CARBOXYLIQUE (S)-INDOLINE-2 ET D'UN ESTER DE METHYLE D'ACIDE CARBOXYLIQUE (S)-INDOLINE-2 A L'AIDE D'UNE ENZYME HYDROLYTIQUE
  申请人：SK CORP

  公开号：WO2005051910A1

  公开（公告）日：2005-06-09

  Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is selected from the group consisting of Savinase, Alcalase, Novozym 243, Everlase, Esperase, Protease 7 and Acylase, whereby (S)-indoline-2-carboxylic acid and methyl ester thereof having an optical purity of at least 99%e.e. can be obtained through a simplified preparation process, thus generating economic benefits.

  本发明公开了一种使用廉价工业可得酶制备（S）-吲哚-2-羧酸和（S）-吲哚-2-羧酸甲酯的方法，该方法能够保证卓越的光学纯度和产率。在此时，水解酶被选择自Savinase，Alcalase，Novozym 243，Everlase，Esperase，Protease 7和Acylase等组中，通过简化的制备过程，可以获得具有至少99%e.e.的光学纯度的（S）-吲哚-2-羧酸和其甲酯，从而产生经济效益。
• [EN] INHIBITORS OF FARNESYL PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA FARNESYL-TRANSFERASE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：WO1997030992A1

  公开（公告）日：1997-08-28

  (EN) This invention relates to compounds that inhibit farnesyl-protein transferase and ras protein farnesylation, thereby making them useful as anti-cancer agents. The compounds are also useful in the treatment of diseases, other than cancer, associated with signal transduction pathways operating through ras and those associated with proteins other than ras that are also post-translationally modified by the enzyme farnesyl protein transferase. The compounds may also act as inhibitors of other prenyl transferases, and thus be effective in the treatment of diseases associated with other prenyl modifications of proteins.(FR) La présente invention concerne des composés inhibant la farnésyl-transférase et la farnésylation de la protéine Ras, ce qui en fait d'utiles agents anticancéreux. Ces composés conviennent également particulièrement au traitement de maladies autres que le cancer, associées aux canaux de transduction de signaux par la protéine Ras, et de maladies associées à des protéines autres que les protéines Ras qui subissent une modification post-translationnelle sous l'effet de la farnésyl-transférase. Ces composés se comportent également comme inhibiteurs d'autres prényl-transférases, et peuvent de ce fait convenir au traitement d'affections associées à d'autres modifications prényl des protéines.

  （中文翻译）本发明涉及抑制法尼醇-蛋白质转移酶和ras蛋白质法尼醇化的化合物，因此使它们成为有用的抗癌剂。这些化合物还适用于治疗与ras信号转导途径以及其他被酶法尼醇蛋白质转移酶后翻译修饰的蛋白质相关的疾病，除了癌症。这些化合物还可以作为其他异戊二烯基转移酶的抑制剂，因此在治疗与其他蛋白质的异戊二烯基修饰相关的疾病方面也很有效。
• Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme
  申请人：Cho Ryune Nahm

  公开号：US20070077632A1

  公开（公告）日：2007-04-05

  Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is selected from the group consisting of Savinase, Alcalase, Novozym 243, Everlase, Esperase, Protease 7 and Acylase, whereby (S)-indoline-2-carboxylic acid and methyl ester thereof having an optical purity of at least 99% e.e. can be obtained through a simplified preparation process, thus generating economic benefits.

  本发明公开了一种使用一种廉价的工业可得酶制备（S）-吲哚-2-羧酸和（S）-吲哚-2-羧酸甲酯的方法，该酶能够保证卓越的光学纯度和收率。此时，水解酶被选择自Savinase、Alcalase、Novozym 243、Everlase、Esperase、Protease 7和Acylase的组合中，通过简化的制备过程可以获得光学纯度至少为99% e.e.的（S）-吲哚-2-羧酸及其甲酯，从而产生经济效益。
• A process for the identification of bacteria and a kit of reagents for use in this process
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0018825A1

  公开（公告）日：1980-11-12

  A procedure for identification of bacteria comprises subjecting the bacteria to a combination of tests for determination of 26 bacterial enzymes, permitting rapid identification by use of tests generally adapted for determination of constitutive enzymes. The procedure generally permits more rapid identification than previous bacterial identification procedures and is universally applicable to a very wide range of bacteria including most bacteria which are commonly encountered clinically. In a particular embodiment the invention includes a procedure for rapid differentation of the bacterial groups Escherichia, Klebsiella spp., Proteus and Pseudomonas spp., comprising subjecting the bacteria to a combination of tests for determination of bacterial acid phosphatase. beta-galactosidase, glutamate decarboxylase, phenylalanine deaminase, cytochrome oxidase, diacetyl producing enzymes and urease. Additionally the invention includes kits for carrying out the procedures of the invention. typically comprising separate specific substrates for each of the enzymes which it is desired to determine, the kit being preferably in the form of a test card or other suitable apparatus comprising a plurality of wells or compartments which separately contain the enzyme substrates.

  细菌鉴定程序包括对细菌进行测定 26 种细菌酶的组合试验，通过使用一般适用于测定组成酶的试验，可快速鉴定细菌。与以前的细菌鉴定程序相比，该程序一般能更快地鉴定细菌，而且普遍适用于各种细菌，包括临床上常见的大多数细菌。在一个特定的实施方案中，本发明包括一种用于快速鉴别埃希氏菌、克雷伯氏菌属、变形杆菌和假单胞菌属细菌的程序，包括对细菌进行测定细菌酸性磷酸酶、β-半乳糖苷酶、谷氨酸脱羧酶、苯丙氨酸脱氨酶、细胞色素氧化酶、双乙酰产酶和脲酶的组合试验。此外，本发明还包括用于执行本发明程序的试剂盒。试剂盒通常包括用于需要测定的每种酶的单独特异性底物，试剂盒最好采用测试卡或其他适当装置的形式，该装置包括多个分别含有酶底物的孔或隔室。
• L-phenylalanine dehydrogenase and use thereof
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0206460A2

  公开（公告）日：1986-12-30

  New L-phenylalanine dehydrogenases produced by a microorganism belonging to the genus Sporosarcina or Bacillus, new microorganisms capable of L-phenylalanine dehydrogenase and belonging to the genus Sporosarcina or Bacillus, a process for production of L-phenylalanine dehydrogenase using the microorganisms, and processes for production of L-amino acids using the enzymes or the microorganisms.

  由属于孢子丝菌属或芽孢杆菌属的微生物产生的新型 L-苯丙氨酸脱氢酶，能够产生 L-苯丙氨酸脱氢酶且属于孢子丝菌属或芽孢杆菌属的新型微生物，使用该微生物生产 L-苯丙氨酸脱氢酶的工艺，以及使用该酶或该微生物生产 L-氨基酸的工艺。