2-[4-(2-Hydroxyethyl)phenoxy]-2-methylpropanoic acid | 1415608-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(2-Hydroxyethyl)phenoxy]-2-methylpropanoic acid
• CAS: 1415608-79-5
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: FXJUEABMXGETGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-[4-(2-hydroxyethyl)phenoxy]-2-methylpropanoate 在 sodium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以74%的产率得到2-[4-(2-Hydroxyethyl)phenoxy]-2-methylpropanoic acid
  参考文献：
  名称：

  Synthesis and structure–activity relationships of fibrate-based analogues inside PPARs

  摘要：

  In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and lipophilic groups derived from natural products chalcone and stilbene were synthesised. Some of them were found to be active at micromolar concentrations only on PPAR alpha or PPAR gamma, while others were identified as dual agonists PPAR alpha/gamma. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.111

文献信息

• Nouveaux acides et esters phénoxy isobutyriques substitués
  申请人：ADIR ET COMPAGNIE

  公开号：EP0621255B1

  公开（公告）日：1997-08-20
• DERIVES DE 1 ,2,4-TRIAZINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE HUMAINE
  申请人：PIERRE FABRE MEDICAMENT

  公开号：EP1856065B1

  公开（公告）日：2009-11-11
• DERIVES D'IMIDAZOLONES SUBSTITUES, PREPARATION ET UTILISATIONS
  申请人：Genfit

  公开号：EP2049107A2

  公开（公告）日：2009-04-22
• [EN] SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES<br/>[FR] DERIVES D'IMIDAZOLONES SUBSTITUES, PREPARATION ET UTILISATIONS
  申请人：GENFIT

  公开号：WO2008012470A2

  公开（公告）日：2008-01-31

  [EN] The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions containing them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives.
  [FR] La présente invention concerne des dérivés d'imidazolones poly-substitués, les compositions pharmaceutiques les comprenant ainsi que leurs applications thérapeutiques dans les domaines de la santé humaine et animale. La présente invention a également trait à un procédé de préparation de ces dérivés.
• Synthesis and structure–activity relationships of fibrate-based analogues inside PPARs
  作者：Letizia Giampietro、Alessandra D’Angelo、Antonella Giancristofaro、Alessandra Ammazzalorso、Barbara De Filippis、Marialuigia Fantacuzzi、Pasquale Linciano、Cristina Maccallini、Rosa Amoroso

  DOI：10.1016/j.bmcl.2012.09.111

  日期：2012.12

  In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and lipophilic groups derived from natural products chalcone and stilbene were synthesised. Some of them were found to be active at micromolar concentrations only on PPAR alpha or PPAR gamma, while others were identified as dual agonists PPAR alpha/gamma. (C) 2012 Elsevier Ltd. All rights reserved.