(5R)-5-(Aminomethyl)-3-(3,5-difluoro-4-iodophenyl)-1,3-oxazolidin-2-one | 827628-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5R)-5-(Aminomethyl)-3-(3,5-difluoro-4-iodophenyl)-1,3-oxazolidin-2-one
• CAS: 827628-43-3
• 化学式: C₁₀H₉F₂IN₂O₂
• 分子量: 354.09
• InChiKey: BUZVWEVAESXFAW-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
  申请人：Fukuda Yasumichi

  公开号：US20050038092A1

  公开（公告）日：2005-02-17

  This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.

  本发明涉及新的含有环丙基基团的噁唑烷酮，对于耐药性较强的革兰氏阳性菌（如多重耐药金黄色葡萄球菌、链球菌和肠球菌）、Bacteroides属、Clostridia属物种以及酸性快速生长菌（如结核分枝杆菌和其他分枝杆菌物种）等厌氧和需氧病原体具有良好的抗菌作用。所述化合物由结构式I表示，其对映异构体、不对称异构体或其药学上可接受的盐或酯。
• Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
  申请人：Fukuda Yasumichi

  公开号：US20070185132A1

  公开（公告）日：2007-08-09

  This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.

  本发明涉及具有环丙基基团的新型噁唑烷酮，对厌氧和厌氧病原体如多重耐药葡萄球菌、链球菌和肠球菌、Bacteroides spp.、Clostridia spp.物种以及抗酸菌如结核分枝杆菌和其他分枝杆菌物种有效。该化合物由结构式I表示：其对映异构体、顺异构体或其药学上可接受的盐或酯。
• CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF
  申请人：Merck & Co., Inc.

  公开号：EP1646629A2

  公开（公告）日：2006-04-19
• US7462633B2
  申请人：——

  公开号：US7462633B2

  公开（公告）日：2008-12-09
• US7582659B2
  申请人：——

  公开号：US7582659B2

  公开（公告）日：2009-09-01