N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[2-[4-[3-(dimethylamino)propoxy]phenyl]phenyl]sulfonyl-2-hydroxy-2-methylpropanamide | 1259938-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[2-[4-[3-(dimethylamino)propoxy]phenyl]phenyl]sulfonyl-2-hydroxy-2-methylpropanamide
• CAS: 1259938-66-3
• 化学式: C₂₉H₃₀F₃N₃O₅S
• 分子量: 589.636
• InChiKey: HYJSQGCTZABTFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal
  申请人：KOH John Tze-tzun

  公开号：US20100331418A1

  公开（公告）日：2010-12-30

  Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.

  本文揭示了一种新型雄激素受体拮抗剂以及与当前处方的抗雄激素治疗失败相关的雄激素受体突变体，以及利用所述拮抗剂治疗与雄激素受体不适当激活相关的疾病的方法。
• US8450374B2
  申请人：——

  公开号：US8450374B2

  公开（公告）日：2013-05-28
• [EN] PAN-ANTAGONISTS FOR THE ANDROGEN RECEPTOR AND ANDROGEN RECEPTOR MUTANTS ASSOCIATED WITH ANTI-ANDROGEN WITHDRAWAL<br/>[FR] PAN-ANTAGONISTES POUR LE RÉCEPTEUR AUX ANDROGÈNES ET MUTANTS DU RÉCEPTEUR AUX ANDROGÈNES ASSOCIÉS À UN RETRAIT D'ANTI-ANDROGÈNE
  申请人：UNIV DELAWARE

  公开号：WO2011008543A2

  公开（公告）日：2011-01-20

  Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.