Bisoprolol Hydrochloride | 85532-43-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bisoprolol Hydrochloride
• 英文别名: 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol;hydrochloride
• CAS: 85532-43-0
• 化学式: C18H32ClNO4
• 分子量: 361.9
• InChiKey: NDIJCSDPVYWQSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.79
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ADHESIVE PATCH CONTAINING BISOPROLOL
  申请人：Nitto Denko Corporation

  公开号：EP2540289A1

  公开（公告）日：2013-01-02

  The invention is intended to provide an adhesive patch which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing of bisoprolol or a salt thereof from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.

  本发明旨在提供一种粘贴剂，它能有效地抑制粘贴剂在储存期间从粘贴剂的粘合层暴露区域渗出或粘出粘合层成分，以及从粘合层渗出比索洛尔或其盐，从而防止药物含量减少。构成粘贴片的支架、离型衬垫和粘合剂层各自形成为矩形平面形状，整个粘贴片形成为矩形平面形状，并且在粘贴片的支架侧表面的一角处形成突起部分。此外，粘贴片还可以形成中间部分和外围部分，突起部分可以形成在矩形中间部分的一个角上。此外，在相邻的至少两个突起部分之间，可以设置一个连接内置部分，其中粘合剂贴片的厚度小于突起部分中粘合剂贴片的厚度。如果离型纸衬垫有分割部分，则分割部分不得穿过突起部分。
• ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH
  申请人：Teikoku Seiyaku Co., Ltd.

  公开号：EP3357945A1

  公开（公告）日：2018-08-08

  The present invention provides a star-shaped acrylic block polymer having a star-shaped structure in which at least three chain polymer portions radiate from a mercapto group situated at the center, wherein (meth)acrylic acid alkyl ester structural units having 7-17 carbon atoms account for 30-99.9% by mass of whole structural units of the star-shaped acrylic block polymer, and at least one of the chain polymer portions has a copolymer structure of polymerizable monomers containing a (meth)acrylic acid alkyl ester having 7-17 carbon atoms and a weakly basic monomer; and a medical patch containing an adhesive composition containing a salt of a basic drug and the star-shaped acrylic block polymer as an adhesive that exhibits high drug efficacy, that does not cause a decrease in adhesive property of an adhesive base due to an additive, and that causes less skin irritation.

  本发明提供了一种星形丙烯酸嵌段聚合物，其具有星形结构，其中至少三个链聚合物部分从位于中心的巯基辐射开来，其中具有 7-17 个碳原子的（甲基）丙烯酸烷基酯结构单元占星形丙烯酸嵌段聚合物整个结构单元质量的 30-99.9%（以质量计）的星形丙烯酸嵌段聚合物的整体结构单元，且至少一个链聚合物部分具有包含具有 7-17 个碳原子的（甲基）丙烯酸烷基酯和弱碱性单体的可聚合单体的共聚物结构；以及一种医用贴片，该贴片包含一种粘合剂组合物，该粘合剂组合物含有碱性药物的盐和星形丙烯酸嵌段聚合物，作为粘合剂，该粘合剂组合物具有高药效，不会因添加剂而导致粘合剂基底的粘合性降低，且对皮肤的刺激性较小。
• Adhesive polymer and medical adhesive patch
  申请人：TEIKOKU SEIYAKU CO., LTD.

  公开号：US11077069B2

  公开（公告）日：2021-08-03

  The present invention provides a star-shaped acrylic block polymer having a star-shaped structure in which at least three chain polymer portions radiate from a mercapto group situated at the center, wherein (meth)acrylic acid alkyl ester structural units having 7-17 carbon atoms account for 30-99.9% by mass of whole structural units of the star-shaped acrylic block polymer, and at least one of the chain polymer portions has a copolymer structure of polymerizable monomers containing a (meth)acrylic acid alkyl ester having 7-17 carbon atoms and a weakly basic monomer; and a medical patch containing an adhesive composition containing a salt of a basic drug and the star-shaped acrylic block polymer as an adhesive that exhibits high drug efficacy, that does not cause a decrease in adhesive property of an adhesive base due to an additive, and that causes less skin irritation.

  本发明提供了一种星形丙烯酸嵌段聚合物，其具有星形结构，其中至少三个链聚合物部分从位于中心的巯基辐射开来，其中具有 7-17 个碳原子的（甲基）丙烯酸烷基酯结构单元占星形丙烯酸嵌段聚合物整个结构单元质量的 30-99.9%（以质量计）的星形丙烯酸嵌段聚合物的整体结构单元，且至少一个链聚合物部分具有包含具有 7-17 个碳原子的（甲基）丙烯酸烷基酯和弱碱性单体的可聚合单体的共聚物结构；以及一种医用贴片，该贴片包含一种粘合剂组合物，该粘合剂组合物含有碱性药物的盐和星形丙烯酸嵌段聚合物，作为粘合剂，该粘合剂组合物具有高药效，不会因添加剂而导致粘合剂基底的粘合性降低，且对皮肤的刺激性较小。
• WOUND CARE FORMULATION
  申请人：Northern Health And Social Care Trust

  公开号：EP2203192A1

  公开（公告）日：2010-07-07
• [EN] WOUND CARE FORMULATION<br/>[FR] FORMULATION DE SOIN POUR PLAIES
  申请人：NORTHERN HEALTH AND SOCIAL CAR

  公开号：WO2009037500A1

  公开（公告）日：2009-03-26

  A gel formulation for use in filling a wound cavity and delivering active ingredient thereto, having a p H range of 6.5 to 7.5, low bioadhesive strength and cohesive integrity and being a PVA borate gel including an active ingredient and a modulator to bind borate and/or PVA in aqueous solution through a mono-diol or di-diol formation and reduces the p H of PVA-borate hydrogels. A suitable modulator is a sugar alcohol such as mannitol and the active ingredient, a medicament suitable for topical application such as a local anaesthetic and/or an antibiotic.