3-[(1R,2R)-2-(methylaminomethyl)cyclohexyl]phenol;hydrochloride | 651312-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(1R,2R)-2-(methylaminomethyl)cyclohexyl]phenol;hydrochloride
• CAS: 651312-76-4
• 化学式: C14H22ClNO
• 分子量: 255.78
• InChiKey: LLVARYHPADNZMH-KYSPHBLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.31
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders
  申请人：Bloms-Funke Petra

  公开号：US20060258741A1

  公开（公告）日：2006-11-16

  Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for treating anxiety, anxiety attacks and disorders as well as depression. Related methods of treating anxiety and anxiety attacks or depression are also provided, including methods of administering the active compounds as adjuvants to an antidepressant.

  [2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢物的药物制剂，用于治疗焦虑、焦虑发作和障碍以及抑郁症。还提供了治疗焦虑和焦虑发作或抑郁症的相关方法，包括将活性化合物作为辅助抗抑郁剂的给药方法。
• C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for Therapy of Fibromyalgia
  申请人：Bloms-Funke Petra

  公开号：US20100004341A1

  公开（公告）日：2010-01-07

  Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof suitable for treating fibromyalgia or chronic pain due to fibromyalgia, and related methods of treating fibromyalgia or chronic pain due to fibromyalgia are described.

  描述了适用于治疗纤维肌痛或由纤维肌痛引起的慢性疼痛的[2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢物的制剂，以及相关的治疗纤维肌痛或由纤维肌痛引起的慢性疼痛的方法。
• C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders
  申请人：Bloms-Funke Petra

  公开号：US20100249225A1

  公开（公告）日：2010-09-30

  Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for treating anxiety, anxiety attacks and disorders as well as depression. Related methods of treating anxiety and anxiety attacks or depression are also provided, including methods of administering the active compounds as adjuvants to an antidepressant.

  [2-(3-甲氧基苯基)-环己基甲基]-二甲胺及其代谢物的制药配方，用于治疗焦虑、焦虑发作和障碍以及抑郁症。还提供了治疗焦虑和焦虑发作或抑郁症的相关方法，包括将活性化合物作为辅助抗抑郁药物进行给药的方法。
• US8084497B2
  申请人：——

  公开号：US8084497B2

  公开（公告）日：2011-12-27