6-Amino-N-{[3-(1-hydroxyethyl)-4-nitrophenyl]methyl}hexanamide | 917762-50-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-Amino-N-{[3-(1-hydroxyethyl)-4-nitrophenyl]methyl}hexanamide
• 英文别名: 6-amino-N-[[3-(1-hydroxyethyl)-4-nitrophenyl]methyl]hexanamide
• CAS: 917762-50-6
• 化学式: C15H23N3O4
• 分子量: 309.36
• InChiKey: FUXPETHYQRIEKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MALDI tissue imaging using conjugates cleavable by fast fragmentation
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2322920A1

  公开（公告）日：2011-05-18

  The invention relates to a method for determining at least one target molecule map in a tissue section, comprising : a) hybridizing said tissue section with at least one (A-X)n-B conjugate, wherein A is a tag molecule of known molecular weight, X is a linker that is cleaved by fragmentation during sample desorption/ionization, n is an integer of at least 1, B is a binding molecule that binds specifically to said target molecule, and each distinct B molecule is linked to a distinct A tag molecule; b) scanning the tissue section surface and analyzing each adjacent spot with a mass spectrometer, wherein said linker X is cleaved by fragmentation during sample desorption/ionization, and wherein the resulting data of each spot is saved; and c) analyzing the obtained data in the molecular mass window(s) of each distinct tag molecule to create as many maps of the tissue section as the number of distinct studied target molecules.

  本发明涉及一种确定组织切片中至少一种靶分子图谱的方法，包括：a) 用至少一种 (A-X)n-B 共轭物杂交所述组织切片，其中 A 是已知分子量的标记分子，X 是在样品解吸/电离过程中通过碎片裂解的连接体，n 是至少 1 的整数，B 是与所述靶分子特异性结合的结合分子，每个不同的 B 分子与一个不同的 A 标记分子连接；b) 用质谱仪扫描组织切片表面并分析每个相邻的斑点，其中所述连接体 X 在样品解吸/电离过程中通过碎片裂解，并保存每个斑点的结果数据；以及 c) 分析每个不同标记分子的分子质量窗口中获得的数据，以创建与所研究的不同目标分子数量相同的组织切片图。
• DNTP conjugated to peptide via a UV cleavable linker
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2322921A1

  公开（公告）日：2011-05-18

  The invention concerns a modified base of formula: or , wherein dNTP represents any triphosphate deoxynucleotide. The invention also relates to conjugate of formula (A-X)n-B, wherein A is a peptide tag molecule of known molecular weight, X is a linker that is cleaved during sample desorption/ionization, n is an integer superior to 1 and B is a nucleic acid probe with a sequence complementary to a target mRNA molecule, wherein the nucleic acid probe comprises at least one modified base according ot the invention. The invention further relates to a method for determining at least one target mRNA molecule map in a tissue section, comprising the use of the conjugate.

  本发明涉及一种式的改良碱： 或 其中 dNTP 代表任何三磷酸脱氧核苷酸。本发明还涉及式（A-X）n-B 的共轭物，其中 A 是已知分子量的肽标签分子，X 是在样品解吸/电离过程中裂解的连接体，n 是大于 1 的整数，B 是具有与靶 mRNA 分子互补序列的核酸探针，其中核酸探针包括至少一个根据本发明修饰的碱基。本发明还涉及一种确定组织切片中至少一个靶 mRNA 分子图的方法，包括使用本发明的共轭物。