Y35N3UL89S | 2658608-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Y35N3UL89S
• 英文别名: 5-bromo-6-(bromomethyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
• CAS: 2658608-79-6
• 化学式: C₁₃H₈Br₂F₄N₂O₂
• 分子量: 460.02
• InChiKey: RXXAQYNMBOSMID-UHFFFAOYSA-N

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-[5-(2-FLUORO-3METHOXYPHENYL)-3-{[2-FLUORO-6-(TRIFLUORO METHYL) PHENYL]METHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS<br/>[FR] PROCESSUS AMÉLIORÉ DE PRÉPARATION D'ACIDE 4-({(1 R)-2-[5-(2-FLUORO-3MÉTHOXYPHÉNYL)-3-{[2-FLUORO-6-(TRIFLUORO MÉTHYL) PHÉNYL]MÉTHYL}-4-MÉTHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHÉNYLÉTHYL}AMINO)BUTANOÏQUE OU DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
  申请人：MSN LABORATORIES PRIVATE LTD R&D CENTER

  公开号：WO2021130776A1

  公开（公告）日：2021-07-01

  The present invention relates to an improved process for the preparation of 4- ((1R) -2- [5- (2-fluoro- 3­ methoxy phenyl) – 3 - [ 2-fluoro- 6-(trifluoro methyl) phenyl] methyl} -4-methyl- 2,6-dioxo- 3,6­dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts. The compound of formula (I) is represented by the following structural formula.

  本发明涉及一种改进的方法，用于制备4-((1R)-2-[5-(2-氟-3-甲氧基苯基)-3-[2-氟-6-(三氟甲基)苯基]甲基}-4-甲基-2,6-二氧杂嘧啶-1(2H)-基]-1-苯乙基}氨基)丁酸(I)或其药学上可接受的盐。式(I)化合物的结构式如下：