Methyl 3-hydroxy-5-propoxybenzoate | 116168-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-hydroxy-5-propoxybenzoate
• CAS: 116168-80-0
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: RKGMWWUEKWIPJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS<br/>[FR] DERIVES D'ACIDE BENZOYL-AMINO-PYRIDYL-CARBOXYLIQUE UTILISES EN TANT QU'ACTIVATEURS DE LA GLUCOKINASE (GLK)
  申请人：ASTRAZENECA AB

  公开号：WO2005054200A1

  公开（公告）日：2005-06-16

  Compounds of Formula: (I); wherein: R¹ is selected from: fluoro, chloro, C1-3alkyl and C1-3alkoxy; R²-X- is selected from: methyl, methoxymethyl and Formula: (X); n is 0,1 or 2; or a salt, pro-drug or solvate thereof are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  式化合物：(I)；其中：R¹选择自：氟、氯、C1-3烷基和C1-3烷氧基；R²-X-选择自：甲基、甲氧甲基和式：(X)；n为0、1或2；或其盐、前药或溶剂化合物。描述了它们作为GLK激活剂的用途，含有它们的药物组合物，以及它们的制备方法。
• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2005080360A1

  公开（公告）日：2005-09-01

  Compounds of Formula (I) wherein: R1 is methyl; R2 is selected from -C (O) NR4R5, SO2NR4R5, S (O) pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C) alkyl and HET-2; R5 is hydrogen or (1-4C) alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them and processes for their preparation are also described.

  分子式为（I）的化合物，其中：R1为甲基；R2选自-C（O）NR4R5，SO2NR4R5，S（O）pR4和HET-2；HET-1是一个5或6元环的、可选地取代的C-连接的杂芳基环；HET-2是一个4、5或6元环的、C-或N-连接的、可选地取代的杂环基环；R3选自卤素、氟甲基、二氟甲基、三氟甲基、甲基、甲氧基和氰基；R4选自氢、可选地取代的（1-4C）烷基和HET-2；R5为氢或（1-4C）烷基；或者R4和R5与它们所连接的氮原子一起可以形成由HET-3定义的杂环基环系统；HET-3例如是一个可选地取代的N-连接的、4、5或6元环的、饱和或部分不饱和的杂环基环；p是（在每次出现时）独立地为0、1或2；m为0或1；n为0、1或2；但当m为0时，则n为1或2；或其盐、前药或溶剂。还描述了它们作为GLK活化剂的用途、含有它们的制药组合物以及它们的制备方法。
• BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS
  申请人：AstraZeneca AB

  公开号：EP1697324A1

  公开（公告）日：2006-09-06
• COMPOUNDS
  申请人：AstraZeneca AB

  公开号：EP1718625A1

  公开（公告）日：2006-11-08
• HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES
  申请人：AstraZeneca AB

  公开号：EP1902052A1

  公开（公告）日：2008-03-26