5-(2-bromo-5-methylphenyl)-3,4-dihydro-2H-pyrrole | 1224945-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-bromo-5-methylphenyl)-3,4-dihydro-2H-pyrrole
• CAS: 1224945-40-7
• 化学式: C₁₁H₁₂BrN
• 分子量: 238.127
• InChiKey: HWGYNZFDEITURT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN<br/>[FR] DÉRIVÉS (PYRROLIDIN-2-YL)PHÉNYLIQUES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA DOULEUR
  申请人：ORGANON NV

  公开号：WO2010052198A1

  公开（公告）日：2010-05-14

  The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula (I), wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; R3 is H, (C1-4)alkyl or halo(C1-4)alkyl; R4 is H, (C1-4)alkyl or halo(C1-4)alkyl; R5 is H, (C1-4)alkyl or halo(C1-4)alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen; R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

  该发明涉及具有通式（I）的（吡咯烷-2-基）苯基衍生物，其中R1为（C1-4）烷基，卤代（C1-4）烷基，（C1-4）烷氧基或卤代（C1-4）烷氧基；R2为H，（C1-4）烷基，卤代（C1-4）烷基，（C1-4）烷氧基，卤代（C1-4）烷氧基或卤素；R3为H，（C1-4）烷基或卤代（C1-4）烷基；R4为H，（C1-4）烷基或卤代（C1-4）烷基；R5为H，（C1-4）烷基或卤代（C1-4）烷基；或者R4和R5，当与同一碳原子结合时，可以与碳原子一起形成一个可选地被卤素取代的螺环（C3-6）环烷基基团；R6为H，（C1-4）烷基，卤代（C1-4）烷基，（C1-4）烷氧基，卤代（C1-4）烷氧基或卤素；或其药学上可接受的盐，以及包含它们的制药组合物，以及这些（吡咯烷-2-基）苯基衍生物用于治疗疼痛，如神经性疼痛或炎症性疼痛。
• (PYRROLIDIN-2-YL)PHENYL DERIVATIVES
  申请人：Grove Simon James Anthony

  公开号：US20100113493A1

  公开（公告）日：2010-05-06

  The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R 1 is (C 1-4 )alkyl, halo(C 1-4 )alkyl, (C 1-4 )alkyloxy, or halo(C 1-4 )alkyloxy; R 2 is H, (C 1-4 )alkyl, halo(C 1-4 )alkyl, (C 1-4 )alkyloxy, halo(C 1-4 )alkyloxy or halogen; R 3 is H, (C 1-4 )alkyl or halo(C 1-4 )alkyl; R 4 is H, (C 1-4 )alkyl or halo(C 1-4 )alkyl; R 5 is H, (C 1-4 )alkyl or halo-(C 1-4 )-alkyl; or R 4 and R 5 , when bonded to the same carbon atom, can together with the carbon atom form a spiro(C 3-6 )cycloalkyl group, optionally substituted with halogen; R 6 is H, (C 1-4 )alkyl, halo(C 1-4 )alkyl, (C 1-4 )alkyloxy, halo(C 1-4 )alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

  该发明涉及具有通式I的（吡咯啉-2-基）苯基衍生物，其中R1为（C1-4）烷基、卤代（C1-4）烷基、（C1-4）烷氧基或卤代（C1-4）烷氧基；R2为H、（C1-4）烷基、卤代（C1-4）烷基、（C1-4）烷氧基、卤代（C1-4）烷氧基或卤素；R3为H、（C1-4）烷基或卤代（C1-4）烷基；R4为H、（C1-4）烷基或卤代（C1-4）烷基；R5为H、（C1-4）烷基或卤代（C1-4）烷基；或者当R4和R5与同一碳原子结合时，它们可以与碳原子一起形成一个可选择地取代卤素的螺环（C3-6）环烷基基团；R6为H、（C1-4）烷基、卤代（C1-4）烷基、（C1-4）烷氧基、卤代（C1-4）烷氧基或卤素；或其药学上可接受的盐，以及含有这些（吡咯啉-2-基）苯基衍生物的药物组合物，以及这些（吡咯啉-2-基）苯基衍生物用于治疗疼痛，如神经痛或炎症性疼痛。
• ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN
  申请人：N.V. Organon

  公开号：EP2356105A1

  公开（公告）日：2011-08-17
• US8188123B2
  申请人：——

  公开号：US8188123B2

  公开（公告）日：2012-05-29