3-(2-trifluoromethoxy-phenylsulfanyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid amide | 853685-90-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-(2-trifluoromethoxy-phenylsulfanyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid amide
• 英文别名: 3-[2-(trifluoromethoxy)phenyl]sulfanyl-1H-pyrrolo[2,3-c]pyridine-2-carboxamide
• CAS: 853685-90-2
• 化学式: C₁₅H₁₀F₃N₃O₂S
• 分子量: 353.325
• InChiKey: FMAKVZIILLADDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon
  申请人：Metz A. William

  公开号：US20050131012A1

  公开（公告）日：2005-06-16

  The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

  本发明公开和声明了一种式（I）的化合物，作为人类酪蛋白激酶IF的抑制剂，并且使用该式（I）的化合物来治疗包括情绪障碍和睡眠障碍在内的中枢神经系统疾病和疾病的方法。还公开和声明了包括式（I）化合物的药用组合物以及制备式（I）化合物的方法。
• SUBSTITUTED 1H-PYRROLO[3,2-b, 3,2-c, and 2,3-c]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Ie
  申请人：METZ William A.

  公开号：US20080200496A1

  公开（公告）日：2008-08-21

  The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase Iε, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

  本发明揭示和声明了化合物公式(I)，其中M为N，K和L均为C，其余取代基在此进一步定义。这些化合物对人类酪蛋白激酶Iε的抑制剂具有有效性，因此在治疗包括情绪障碍和睡眠障碍在内的中枢神经系统疾病和疾病中有用。还揭示和声明了包含化合物公式(I)的制药组合物和制备化合物公式(I)的方法。
• SUBSTITUTED 1H-PYRROLO 3,2-B, 3,2-C, AND 2,3-C¨PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1747220A1

  公开（公告）日：2007-01-31
• SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1747220B1

  公开（公告）日：2009-04-15
• US7402672B2
  申请人：——

  公开号：US7402672B2

  公开（公告）日：2008-07-22